Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
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Rejuran I is a polynucleotide booster for the under-eye area; a split-face trial of 27 subjects found improved skin roughness and elasticity around the eyes.
To choose a good Rejuran I clinic in Gangnam, Seoul, prioritise doctor-led injection technique in the delicate under-eye area, a clear multi-session protocol, and honest expectations. At our Gangnam (Seoul) location, Dr. Yoongon Ryu assesses your under-eye concern first, then tailors the polynucleotide plan, since technique matters most around the eyes.
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Rejuran I is the version of the Rejuran polynucleotide (PN) skin booster formulated specifically for the delicate under-eye and periorbital area. Polynucleotides are long-chain DNA fragments, purified from salmon, that support skin repair by stimulating fibroblasts, improving microcirculation, and boosting collagen and elastin. Compared with the standard formula, Rejuran I has a finer, lighter consistency suited to the thin skin around the eyes, where precision and gentle placement matter.
Around the eyes, Rejuran I is used to improve skin quality, fine lines, crepey texture, and the dull or bluish tone that contributes to the appearance of dark circles. It is not a volumiser and does not replace filler for true hollowing; instead, it works on skin regeneration and tone. Because it enhances microcirculation and thickens thin under-eye skin over time, many patients notice a fresher, less tired look once the series is complete and collagen has had time to build.
Choosing the right clinic matters especially for the under-eye area, where anatomy is delicate and technique affects both safety and results. At our Gangnam (Seoul) location, care is consultation-led and international-patient friendly with full English support. Dr. Yoongon Ryu evaluates whether Rejuran I suits your concern, whether it should be combined with other treatments, and how many sessions are realistic in Gangnam, Seoul, Korea.
Rejuran I works through polynucleotides, purified salmon-derived DNA fragments that act as a biostimulator rather than a filler. Once placed into the thin under-eye skin, polynucleotides bind water and create a supportive scaffold, while signalling fibroblasts to produce fresh collagen and elastin. They also upregulate vascular endothelial growth factor (VEGF), improving microcirculation, which is relevant under the eyes because sluggish circulation and thin skin let underlying vessels show through as bluish darkness. By thickening and regenerating the skin and improving blood flow, Rejuran I addresses skin-quality contributors to dark circles and crepey texture rather than adding volume. Because the periorbital area is delicate and vascular, placement technique is critical: a good clinic uses fine needles or cannula, conservative depth, and careful mapping to reduce the risk of bruising or swelling. The clinic’s doctors also determine whether Rejuran I alone suits your under-eye concern or whether pairing it with other treatments will serve you better, since true tear-trough hollowing, pigmentation, and skin texture are different problems that may call for different tools. That is exactly why an in-person assessment precedes any injection plan.
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Doctors examine 3 concerns (skin texture, tone, and fine lines) suited to Rejuran I, versus true hollowing that may need a different option.
Topical numbing cream is applied for about 20 to 30 minutes so injections into the delicate periorbital skin stay comfortable.
Fine needles or a cannula deposit small amounts of PN into the thin under-eye skin at a conservative, carefully mapped depth.
Polynucleotides signal fibroblasts to build collagen and elastin and boost VEGF-driven microcirculation over the following 4 to 6 weeks.
A typical course is about 3 sessions spaced roughly 2 to 4 weeks apart, as clinical studies used a 3-injection protocol.
Skin quality, tone, and fine texture improve over 4 to 8 weeks as new collagen forms, so results build rather than appearing at once.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
Dr. Yoongon Ryu assesses your under-eye concern, distinguishing skin quality from true hollowing, and explains whether Rejuran I fits and how many sessions are realistic, in English.
After about 20 to 30 minutes of numbing, the injection itself is quick, usually taking around 10 to 15 minutes for the under-eye area.
Rejuran I is planned as a course, commonly about 3 sessions spaced roughly 2 to 4 weeks apart rather than a single visit.
Skin quality and tone improve gradually over several weeks as collagen forms, with the fuller effect visible after the completed series.
Results are supported by occasional maintenance every several months, plus sun protection and gentle under-eye skincare to preserve the improvement.
Prioritise doctor-led injection technique for the delicate under-eye area, careful assessment of whether your concern is skin quality or hollowing, a clear multi-session protocol, and honest expectations. A good clinic advises a different or combined treatment when it suits you better. You can learn more on our Rejuran page before consulting.
Rejuran I is provided at our Gangnam (Seoul) location, in the Gangnam-daero area about 2 minutes from Gangnam Station exit 10, led by Dr. Yoongon Ryu with full English support. International patients can also be seen across our Seoul-area locations depending on scheduling and the plan agreed at your consultation.
Rejuran I contains polynucleotides, long-chain DNA fragments purified from salmon, in a finer, lighter formula designed for the thin skin around the eyes. These act as a biostimulator, prompting collagen production and improving microcirculation, rather than adding volume like a filler. Its consistency suits the delicate periorbital area, which is why it differs from the standard Rejuran formula.
Rejuran I improves the skin-quality causes of dark circles, such as thin, dull, or crepey under-eye skin and sluggish microcirculation, rather than every cause. If your dark circles come mainly from true hollowing or pigment, filler or pigment treatment may suit better. Your doctor identifies the cause first so the right tool, or combination, is chosen for you.
No, Rejuran I is a polynucleotide biostimulator that regenerates skin, while filler is cross-linked hyaluronic acid that adds structural volume. Rejuran I improves texture, tone, and thickness over weeks but does not fill a hollow instantly. For true tear-trough shadows, an injectable filler may be more appropriate, which your doctor discusses at consultation.
Discomfort is manageable because topical numbing cream is applied for about 20 to 30 minutes before treatment. Most patients feel small pinches during the injections into the thin under-eye skin. Because the area is delicate, a gentle technique is used. Any tenderness settles quickly, and your doctor works carefully to keep the session as comfortable as possible.
A typical course is around 3 sessions spaced roughly 2 to 4 weeks apart, matching the protocol used in clinical studies, though your exact number depends on your skin and goals. Some patients add maintenance later. Dr. Ryu confirms your session count at consultation after assessing your under-eye skin quality and any combined treatments.
Downtime is usually short, though the delicate under-eye area can bruise or swell briefly after injection. Most swelling settles within a few days, and small bumps from the product typically smooth out over a similar period. Your doctor advises on gentle aftercare, and you can plan social events with a little buffer around your appointment to be safe.
Improvement builds gradually over several weeks as new collagen forms and microcirculation improves, not immediately after one session. Skin often looks smoother and more refreshed after the completed series rather than on injection day. Because it is regenerative, patience through the course gives the most rewarding under-eye change, which your doctor tracks between visits.
Results typically last several months once the series is complete, and many patients maintain them with a top-up session every few months. Because Rejuran I works by regenerating skin rather than filling, its effect fades gradually rather than abruptly. Sun protection and gentle under-eye care help preserve the improvement, which your doctor factors into your maintenance plan.
Yes, Rejuran I is often combined with other under-eye approaches when appropriate, such as filler for true hollowing or energy treatments for texture, and your doctor sequences them safely. For firmness or texture goals, treatments like laser treatment may complement it. The right combination is decided at consultation based on the cause of your concern.
Cost depends on the number of sessions, whether Rejuran I is combined with other treatments, and your individual plan, so it is set at consultation rather than a fixed price. A full course costs more than a single session, and combined plans vary. The clinic’s doctors explain your transparent, personalised cost in English before you start.
Good candidates have dull, crepey, or fine-lined under-eye skin and want regeneration rather than volume. A consultation rules out contraindications such as salmon allergy or pregnancy. If your main concern is a true hollow, your doctor may recommend an injectable filler instead or alongside for the most satisfying outcome.
Rejuran I is widely used and generally considered safe around the eyes when injected by a doctor using careful, conservative technique in this delicate, vascular area. Temporary bruising or swelling are the main effects. A consultation screens for contraindications like salmon allergy or blood-thinning medication. You can review the broader approach on our Rejuran page first.
Keep the area clean, avoid rubbing or heavy makeup on injection day, and skip saunas, intense exercise, and alcohol for a day or two to limit swelling. Daily sunscreen protects the regenerating skin. A gentle under-eye skin care routine supports results, and your doctor gives specific guidance based on how your skin responds.
For a first session, 2 to 3 days is comfortable, allowing a consultation, the treatment, and time for any brief swelling to settle before travel. Because Rejuran I is a course, many international patients begin in Seoul and continue on later trips. Our English-speaking team helps schedule sessions around your travel and any other treatments.
Yes, flying within a day or so is generally fine, though the under-eye area may show mild bruising or swelling briefly after injection. Cabin air is drying, so moisturise gently and protect the skin from sun. If you bruise easily, allowing a short buffer before travel or an important event is sensible, and your doctor can advise.
| Rejuran I (Polynucleotide) | HA Skin Booster | Under-Eye Filler | |
|---|---|---|---|
| Mechanism | Salmon PN stimulates collagen and microcirculation | Hyaluronic acid hydrates and plumps skin | Cross-linked HA adds volume to hollows |
| Best for | Skin quality, fine lines, dull tone under the eyes | Hydration and mild skin quality improvement | True tear-trough hollowing and shadowing |
| Volume effect | Minimal; regenerates rather than fills | Minimal to light plumping | Adds structural volume |
| Pain / comfort | Manageable with numbing cream | Manageable with numbing | Manageable with numbing or cannula |
| Downtime | Possible brief bruising or swelling | Usually minimal | Possible bruising or puffiness briefly |
| Results timeline | Builds over weeks as collagen forms | Fairly quick hydration, builds with sessions | Immediate volume, settles over days |
| Sessions | Often around a 3-session course | A planned series | Often single with periodic top-ups |
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