Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices · Featured in Authority Magazine (2026)
Rejuran Healer is a polynucleotide (PN) skin-booster injection that restores skin quality from within, available at Reberry Clinic for international patients across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport).
Using purified polynucleotides extracted from salmon DNA, Rejuran Healer works at the cellular level to stimulate fibroblasts, boost collagen and elastin, improve hydration and calm inflammation. This minimally invasive treatment refines skin texture, tightens pores, softens fine lines and strengthens the skin barrier, so the complexion looks smoother, firmer and more naturally radiant. A typical course is three to four sessions spaced three to four weeks apart, with maintenance every three to six months to sustain the regenerative effect.
Rejuran Healer is an injectable polynucleotide (PN) skin booster made from purified salmon DNA that repairs skin from within, stimulating fibroblasts to build collagen and elastin. A course of three to four sessions spaced three to four weeks apart suits adults wanting smoother texture, smaller pores, firmer elasticity and calmer, healthier skin without surgery.
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Rejuran Healer is a minimally invasive injectable skin booster that helps skin rejuvenate itself from the inside out. Its active ingredient is polynucleotide (PN), a long-chain DNA fragment purified from salmon, which is closely compatible with human tissue. Delivered through fine microinjections into the dermis, PN stimulates the skin’s own repair machinery to rebuild collagen and elastin, improve hydration, refine texture, smooth fine lines and calm redness. It is commonly performed on the forehead, cheeks, under-eyes and jawline to target wrinkles, uneven texture and loss of firmness.
Unlike hyaluronic-acid fillers that add volume by sitting under the skin, Rejuran Healer is a regenerative treatment: it does not fill or volumise but improves the underlying quality and resilience of the skin over time. Because PN works by triggering your body’s natural healing pathways rather than masking concerns, results build gradually across a course of sessions, typically three to four treatments spaced three to four weeks apart. It also pairs well with energy and laser treatments to amplify skin renewal.
Treatment is performed at Reberry Clinic by the clinic’s doctors, with English-speaking support for international patients. A consultation maps a plan to your skin type and concerns; see our Rejuran Healer page for details.
Rejuran Healer uses purified polynucleotides (PN), a DNA-based compound extracted from salmon, that accelerate cellular repair and help restore the skin’s natural barrier. Polynucleotides are long-chain nucleotide fragments highly compatible with human tissue, which is why they are well tolerated even by sensitive skin. Once injected into the dermis, PN acts on the skin’s own biology rather than adding foreign volume.
At the cellular level, polynucleotides stimulate fibroblasts to synthesise new collagen and elastin, the proteins that give skin its firmness and bounce. PN also activates adenosine A2A receptors, a pathway shown in the research to drive tissue repair, support new blood-vessel formation and reduce inflammation. In addition, PN holds water within the dermis to improve hydration retention. Together these actions remodel the extracellular matrix, so over a course of three to four sessions the skin becomes smoother, more elastic, better hydrated and visibly more resilient.
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At Reberry Clinic we have helped international patients improve skin quality with tailored Rejuran Healer treatment. Each course is customised to the individual’s skin concerns, whether early ageing, enlarged pores, acne scars, dullness or a weakened skin barrier, and typically involves three to four sessions. Patients commonly report smoother texture, improved elasticity and a healthier, more even complexion. Results vary from person to person depending on skin condition, age and adherence to the recommended course, and are not guaranteed; a consultation is the most reliable way to understand what Rejuran Healer can realistically achieve for your skin.
We offer services at three convenient Seoul locations: our Myeongdong Branch, situated in the city centre close to major tourist attractions, our Incheon Airport Branch, easily accessible from the terminals and ideal for travellers needing medical care during transit or brief visits, and our Gangnam Branch, located in Seoul’s upscale district, perfect for those seeking premium care alongside shopping and dining.
We maintain fair, transparent pricing for both patients; local and international patients. There are no hidden fees and no pricing differences based on nationality.
At our dermatology clinic in Seoul, we use FDA-cleared injectable fillers and advanced injection techniques. You receive high-performance, effective treatments without the inflated luxury clinic prices.
Your consultation is never delegated. Our lead physician meets with you directly to provide expert evaluation, personalized treatment advice, and trusted medical care from start to finish.
We combine advanced aesthetic care with competitive pricing. Enjoy custom treatment plans that reflect your unique needs without compromising on quality or results.
Rejuran Healer, Juvelook and exosome therapy are all regenerative skin treatments that improve skin quality through different active ingredients and mechanisms — here is how they compare.
| Rejuran Healer | Juvelook | Exosome therapy | |
|---|---|---|---|
| Active / mechanism | Salmon-derived polynucleotide (PN); repairs skin and stimulates fibroblasts via A2A receptors | PDLLA microspheres plus carrier; stimulates collagen and adds subtle firmness | Cell-derived exosomes carrying growth factors; signal skin cells to regenerate |
| Best for | Texture, fine lines, pores, elasticity and barrier repair | Collagen building with mild volumising and firmness | Overall rejuvenation, redness and post-procedure recovery |
| Pain / comfort | Mild; numbing cream applied, brief pinches | Mild to moderate; numbing cream applied | Mild; often delivered with microneedling or after laser |
| Downtime | Minimal; redness and small bumps for 1-3 days | Minimal; possible bumps and swelling for a few days | Minimal; transient redness |
| Results timeline | Builds over a course of 3-4 sessions across weeks | Gradual over 2-3 months as collagen forms | Gradual over weeks; often used as a booster |
| Longevity | Long-lasting with maintenance every 3-6 months | Around 12-18 months depending on skin | Shorter; typically repeated in a series |
| Sessions | Usually 3-4, then periodic maintenance | Often 1-2 sessions, repeated periodically | Usually a series of sessions |
Polynucleotide (PN) skin boosters such as Rejuran Healer are supported by a growing body of peer-reviewed research on salmon-derived DNA fragments and their close relative polydeoxyribonucleotide (PDRN). In a prospective observational study of 42 patients receiving intradermal polynucleotide injections for periorbital wrinkles, validated FACE-Q scores improved significantly at 1, 3 and 6 months (p < 0.001), with the greatest gains and highest satisfaction at 3 months after two sessions and minimal adverse events. Mechanistic work explains why: polynucleotides activate adenosine A2A receptors, stimulating fibroblast proliferation, VEGF-driven angiogenesis and collagen synthesis while reducing inflammation, the same salvage-pathway biology that underpins PDRN's documented role in tissue repair. A 2024 survey of Korean aesthetic medicine specialists found injectable polynucleotide was the most widely used skin booster, performed by 88% of respondents, with around 31% frequently using it for depressed and acne scars. Comparative reviews note that PN's longer DNA chains are particularly suited to extracellular-matrix remodelling, the foundation of the texture, elasticity and barrier improvements patients report.
Rejuran Healer is a polynucleotide (PN) skin booster made from purified salmon DNA that repairs skin from within rather than adding volume. Injected into the dermis, it stimulates fibroblasts to build collagen and elastin, improving texture, elasticity and hydration. See our Rejuran Healer page for full details and consultation booking.
Rejuran Healer suits adults of any gender with early signs of ageing, enlarged pores, acne scars, dull or uneven tone, or a weakened skin barrier. It is ideal for those wanting natural, non-surgical skin rejuvenation without dramatic downtime. A consultation confirms suitability, and it can be combined with other injection treatments for your goals.
Hyaluronic acid boosters mainly hydrate and add temporary plumpness, while Rejuran Healer works at the cellular level to repair tissue, recruit fibroblasts and rebuild collagen for longer-term skin quality. One hydrates the surface; the other regenerates the structure. Many patients combine boosters with regenerative injectable treatments based on their concerns and consultation.
Most patients see visible improvement after the first session, but a course of three to four treatments spaced three to four weeks apart is typically recommended for optimal, longer-lasting results. Maintenance sessions every three to six months then help prolong the regenerative benefits. The clinic’s doctors confirm the right schedule for your skin during consultation.
Discomfort is generally mild because a topical numbing cream is applied for 20 to 30 minutes before treatment. You may feel small pinches as the microinjections are placed, and some areas such as under-eyes can be more sensitive. The session itself takes only about 20 to 30 minutes, and any stinging sensation settles quickly once injections are complete.
Downtime is minimal. You may notice mild redness, tiny bumps or slight swelling at the injection sites, which usually resolve within 1 to 3 days. Most patients return to daily activities immediately or the next day. The small bumps flatten as the polynucleotide solution absorbs, so planning a session a couple of days before key events is sensible.
Many patients notice fresher, smoother skin within two to three weeks of the first session, with results building across the full course as collagen forms. Benefits are long-lasting but not permanent, since Rejuran Healer enhances your skin’s own renewal. Maintenance sessions every three to six months sustain the improvements in texture, elasticity and radiance over time.
Yes. Rejuran Healer is generally well tolerated by sensitive and acne-prone skin because polynucleotides are highly compatible with human tissue and have anti-inflammatory, barrier-repairing properties. Over a course of sessions it can help calm irritation, strengthen the skin barrier and reduce post-acne redness or scarring, making it a gentle option for reactive or compromised skin.
Yes. By recruiting fibroblasts and remodelling the dermal matrix, Rejuran Healer can gradually soften shallow, depressed acne scars and improve overall texture over a course of treatments. For deeper or more stubborn scarring, the clinic’s doctors may combine it with laser treatment to enhance results. A consultation determines the right plan for your scars.
Each treatment session takes roughly 20 to 30 minutes, plus 20 to 30 minutes beforehand for the numbing cream to take effect. Your initial consultation is a separate 60-minute appointment in which the clinic’s doctors assess your skin and design the course. Because the procedure is quick and low-downtime, it fits easily into a short visit to Seoul.
Side effects are usually mild and temporary: redness, slight swelling, tiny bruises or small bumps at the injection sites that settle within a few days. Serious complications are uncommon when treatment is performed by qualified professionals. Rejuran Healer is generally avoided during pregnancy or breastfeeding and over active skin infections; a consultation reviews your history first.
Yes. Rejuran Healer is often paired with treatments that add volume or tighten skin, such as Juvelook or energy-based lifting, because it improves skin quality while they address contour or laxity. The clinic’s doctors sequence treatments so the timing is safe and each works to full effect, with the plan tailored during your consultation.
Aftercare is simple but important. Avoid makeup for at least 24 hours so skin can absorb the solution and recover, and skip saunas, intense exercise and alcohol for a day or two. Apply daily sunscreen, keep skin hydrated and avoid picking at any bumps. The clinic’s doctors give personalised aftercare advice and schedule your next session in the course.
Both are regenerative skin boosters, but they use different active ingredients. Rejuran Healer uses salmon-derived polynucleotides to repair and rejuvenate skin, while Juvelook uses PDLLA microspheres to stimulate collagen and add subtle firmness. Some patients use one, others combine them; the clinic’s doctors advise which fits your skin quality and goals during consultation.
Rejuran Healer is commonly used on the forehead, cheeks, under-eyes and jawline to improve texture, fine lines, enlarged pores and elasticity. The under-eye area in particular benefits from its gentle, regenerative action. It can also be applied to the neck and other areas of crepey or dull skin. Your consultation determines which zones will benefit most for your goals.
Only briefly. It is best to avoid makeup for at least 24 hours after Rejuran Healer so the skin can fully absorb the solution and recover without irritation. Beyond that, most people resume normal routines immediately. Any small bumps or redness fade within a day or two, after which you can return to your usual skincare and makeup as advised by your doctor.
Rejuran Healer has minimal downtime, so it fits a short visit, though a full course of three to four sessions is ideal. Many international patients start a session or two in Seoul and continue maintenance at home. Reberry Clinic offers English-speaking support and three Seoul-area locations, including one at Incheon Airport, convenient for arrival or departure.
Rejuran Healer, Juvelook and exosome therapy are all regenerative skin treatments that improve skin quality through different active ingredients and mechanisms — here is how they compare.
| Rejuran Healer | Juvelook | Exosome therapy | |
|---|---|---|---|
| Active / mechanism | Salmon-derived polynucleotide (PN); repairs skin and stimulates fibroblasts via A2A receptors | PDLLA microspheres plus carrier; stimulates collagen and adds subtle firmness | Cell-derived exosomes carrying growth factors; signal skin cells to regenerate |
| Best for | Texture, fine lines, pores, elasticity and barrier repair | Collagen building with mild volumising and firmness | Overall rejuvenation, redness and post-procedure recovery |
| Pain / comfort | Mild; numbing cream applied, brief pinches | Mild to moderate; numbing cream applied | Mild; often delivered with microneedling or after laser |
| Downtime | Minimal; redness and small bumps for 1-3 days | Minimal; possible bumps and swelling for a few days | Minimal; transient redness |
| Results timeline | Builds over a course of 3-4 sessions across weeks | Gradual over 2-3 months as collagen forms | Gradual over weeks; often used as a booster |
| Longevity | Long-lasting with maintenance every 3-6 months | Around 12-18 months depending on skin | Shorter; typically repeated in a series |
| Sessions | Usually 3-4, then periodic maintenance | Often 1-2 sessions, repeated periodically | Usually a series of sessions |
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Published studies related to this treatment area. Individual results vary; consult a physician for personal advice.
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