Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Botulinum toxin injected into the palms blocks the sweat-gland signal, reducing sweating within 1 to 2 weeks and lasting about 4 to 6 months per session.
Palm hyperhidrosis, or excessive hand sweating, is most commonly treated with botulinum toxin injected across the palm, where it blocks the acetylcholine signal that switches on sweat glands. Sweating drops within about 1 to 2 weeks and stays reduced for roughly 4 to 6 months, after which the treatment is repeated to maintain dry palms.
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Palm hyperhidrosis, also called primary palmar hyperhidrosis, is excessive sweating of the hands beyond what the body needs to cool itself. It happens because the eccrine sweat glands in the palms are overactive, triggered by cholinergic nerve signals rather than by heat or exercise alone. For many people it starts in youth, runs in families, and can make handshakes, writing, phone use, and gripping tools genuinely difficult.
Botulinum toxin type A is the most established in-clinic option for moderate to severe cases. Injected as a grid of tiny doses across each palm, it blocks the release of acetylcholine at the nerve endings that switch on the sweat glands, temporarily turning off local sweating. The effect appears within days, settles over about 1 to 2 weeks, and typically lasts 4 to 6 months before a repeat session is needed.
For international patients near Hongdae (Hongik Univ.) Station — 홍대입구역, care is provided across our Seoul locations (Gangnam, Myeongdong), easily reached from 홍대입구역. At Reberry Clinic, the clinic’s doctors first confirm the sweating is primary, grade its severity, and explain the plan in English before any treatment.
Sweat glands in the palm are eccrine glands driven by cholinergic sympathetic nerves, whose signalling chemical is acetylcholine. When the nerve fires, acetylcholine is released and binds receptors on the sweat-gland cells, prompting them to produce sweat. Botulinum toxin type A works by blocking that acetylcholine release at the nerve ending, so the local glands stop receiving the message to sweat. Because the toxin acts only where it is injected, the rest of the body sweats normally and thermoregulation is preserved. The doctor places a grid of small intradermal injections roughly 1 to 1.5 cm apart across each palm, so the whole sweating zone is covered. The effect is temporary because nerve terminals gradually regenerate their signalling over months, which is why sweating returns after about 4 to 6 months and the treatment is repeated. Careful dosing and placement matter on the palm because it contains small hand muscles, so an experienced injector balances thorough sweat control with preserving hand function.
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The doctor confirms it is primary sweating and grades severity, often on a 4-point scale, to plan the dose.
Because the palm is sensitive, topical numbing or cooling is applied for about 15 to 30 minutes before injecting.
A grid of injection points spaced roughly 1 to 1.5 cm apart is marked so the whole sweating area is covered.
Botulinum toxin is placed at each of the many points across each palm, usually taking about 20 to 40 minutes total.
Sweating drops over 1 to 2 weeks, and a follow-up around 2 weeks checks the result and any touch-up.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors confirm primary sweating, grade severity, and plan your dose and injection map, explaining everything in English.
After 15 to 30 minutes of numbing, the injections take about 20 to 40 minutes across both palms.
Effects settle over 1 to 2 weeks as the toxin quiets the sweat glands, with sweating steadily reducing.
Dryness lasts about 4 to 6 months, and a follow-up around 2 weeks confirms the result and any small touch-up.
As the effect fades over months, a repeat session restores dryness, and simple aftercare protects the result.
Palm hyperhidrosis is excessive sweating of the hands beyond the body’s cooling needs, caused by overactive eccrine sweat glands. It often begins in youth and can run in families, making handshakes, writing, and gripping difficult. It is treatable, most commonly with botulinum toxin, which you can explore on our botox injection page.
Botulinum toxin type A blocks the release of acetylcholine at the nerve endings that switch on the palm’s sweat glands, so those glands stop producing sweat locally. Because it acts only where injected, the rest of your body sweats normally. Studies confirm sweat production falls sharply within about a month of treatment.
The palm is sensitive, so most patients feel brief stinging during the grid of small injections. To manage this, topical numbing or cooling is applied for about 15 to 30 minutes beforehand. The whole injecting step usually takes 20 to 40 minutes, and your doctor paces it for comfort during a supervised injection treatment.
Sweating usually starts dropping within a few days and settles fully over about 1 to 2 weeks after the session. A double-blind trial showed a sharp fall in sweat production by day 28. Your doctor schedules a follow-up around 2 weeks to confirm the result and add any small touch-up if needed.
Palm results typically last about 4 to 6 months per session, and some patients find repeated treatments extend the effect toward 7 months or more. Because it is temporary, the treatment is repeated to keep palms dry. Your doctor plans your personal re-treatment interval based on how your results fade.
Temporary, mild hand-muscle weakness can occasionally occur because the palm has small muscles near the injection sites, but it is usually short-lived. Research reports the treatment reduces sweating without a lasting effect on grip strength. Careful dosing and placement by your doctor keep this risk low.
Each session is a single treatment that lasts about 4 to 6 months, so you repeat it roughly once or twice a year rather than doing a course upfront. Many patients settle into a predictable rhythm. You can plan your schedule during a botox consultation with the clinic’s doctors.
Yes, patients with sweaty palms sometimes also treat underarms or soles, though each area is dosed separately. Interestingly, some studies note plantar (sole) sweating can improve alongside palm treatment. Your doctor tailors a plan across the areas that bother you most, explained clearly during your consultation.
Common effects are temporary and minor: brief tenderness, small bruises, or short-lived, mild hand-muscle weakness. Serious effects are uncommon when a trained doctor doses correctly. A consultation screens for contraindications like pregnancy or neuromuscular conditions. You can review the overall approach on our botox injection page first.
Most adults with moderate to severe primary palm sweating that disrupts daily life are suitable, especially if antiperspirants have not helped. A consultation confirms the sweating is primary, not caused by another condition, and grades severity. Pregnancy, breastfeeding, and some neuromuscular disorders are contraindications your doctor reviews first.
Topical antiperspirants suit mild sweating and need frequent application, while iontophoresis is a drug-free device routine needing regular upkeep. Botulinum toxin suits moderate to severe sweating, giving months of relief from one session. Your doctor helps you weigh convenience, onset, and longevity during a consultation.
Botulinum toxin for palms is widely performed and generally considered safe when a trained doctor doses and places it correctly and screens for contraindications. Reported side effects are usually minor and temporary. Choosing an experienced injector reduces risks, and your severity and health history are reviewed at consultation before treatment.
Aftercare is simple: for the first day, avoid heavy gripping, hot water, saunas, and vigorous hand rubbing so the toxin settles where placed. There are usually no special products required. Following this brief guidance helps the result develop evenly, and your doctor explains it clearly before you leave the clinic.
Patients near Hongdae (Hongik Univ.) Station — 홍대입구역 are cared for at our Seoul locations (Gangnam and Myeongdong), both easily reached from 홍대입구역 with full English support. You can book an injection consultation and our team helps you pick the most convenient Seoul location.
For a single palm session, 1 to 2 days is comfortable, allowing a consultation, the treatment, and a short check. The procedure takes under an hour including numbing. Many international patients combine it with other appointments, and our English-speaking team helps coordinate timing around your travel plans.
Yes, flying within a day or so is generally fine, as the treatment is minimally invasive with no significant downtime. Simply avoid heavy gripping and very hot water on the day. Any brief tenderness settles quickly, and your doctor provides simple, travel-friendly aftercare so your hands recover comfortably.
International patients can time repeat sessions to future Seoul trips, roughly every 4 to 6 months, and the clinic offers remote check-ins in English between visits. Your treatment notes, including your unit dose, are kept on file so dosing stays consistent. You can plan this during your first botox consultation.
| Botulinum Toxin (Palms) | Topical Antiperspirants | Iontophoresis | |
|---|---|---|---|
| Mechanism | Blocks acetylcholine at sweat-gland nerve endings | Aluminium salts plug sweat-duct openings | Mild electric current reduces gland activity |
| Best for | Moderate to severe palm sweating | Mild sweating or a first-line step | Those wanting a drug-free device routine |
| Onset | Within days, settling over 1 to 2 weeks | Gradual, only while used | Over several sessions of use |
| Downtime | Minimal, brief tenderness possible | None, possible skin irritation | None, occasional tingling |
| Longevity | About 4 to 6 months per session | Only while applied consistently | Needs ongoing maintenance sessions |
| Effort | One session every few months | Frequent at-home application | Repeated device sessions |
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