Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Rejuran i is the eye-area polynucleotide (PN) booster; results build across about 3 sessions and commonly hold for several months, with each boost felt for roughly 2 to 4 months.
Rejuran i results in Korea typically last several months per completed course, with each individual under-eye boost most noticeable for about 2 to 4 months. As the eye-area polynucleotide (PN) booster, it thickens and strengthens delicate periocular skin gradually over roughly 3 sessions, then fades slowly, so a maintenance visit every few months sustains the improvement.
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Rejuran i is the polynucleotide (PN) booster formulated for the delicate skin around the eyes, using purified salmon DNA fragments to strengthen and thicken thin periocular skin. Its longevity is not a single number: because it repairs skin quality gradually, the benefit builds across a course of about 3 sessions and then declines slowly rather than stopping abruptly. Most patients feel a completed course holds for several months.
Think of it in two phases. Each individual boost is most noticeable for roughly 2 to 4 months as new collagen and hydration peak in the under-eye area, while the cumulative benefit of a full course of about 3 sessions carries improved texture, thickness, and a smoother look for several months. Skin thinness, dark-circle type, age, and screen or sun exposure all shift where you land in that range. Rejuran i addresses skin quality and fine crepiness, not fat-pad volume, so its duration reflects a skin-repair effect.
For international patients, Rejuran i is a signature reason to visit Seoul, where the Rejuran range originated. Reberry Clinic serves visitors across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport), with English-language consultation and treatment planned and reviewed by the clinic’s doctors, who set a realistic longevity expectation for your eye area.
Rejuran i uses polynucleotides: high-molecular-weight DNA fragments purified from salmon milt and processed to remove proteins for biocompatibility, in a formulation suited to fragile eye-area skin. Micro-injected into the shallow dermis around the eyes, these chains form a temporary scaffold that signals fibroblasts to make new collagen and helps the skin hold water. The scaffold is naturally resorbed over weeks, which is why the treatment is not a one-time fix and why results taper rather than vanishing. The new collagen laid down during the course is what carries the several-month benefit, and repeating a session before that collagen turns over is how longevity is maintained.
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Across about 3 sessions spaced 2 to 4 weeks apart, collagen accumulates in the delicate under-eye skin.
The fullest thickness and texture benefit is usually seen 4 to 8 weeks after the final session.
For several months the improved eye-area skin quality holds as new collagen matures and stabilises.
Over roughly 2 to 4 months the effect of each boost softens as the polynucleotide scaffold is resorbed.
A top-up session every few months, typically 1 visit, refreshes collagen and sustains the result.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors assess your eye-area skin and dark-circle type, setting a realistic longevity expectation in English.
After numbing, the under-eye micro-injection session takes about 15 to 20 minutes, with the visit under an hour.
A full plan is usually about 3 sessions spaced 2 to 4 weeks apart to reach peak longevity.
Thickness and texture peak roughly 4 to 8 weeks after the final session, then hold for several months.
Effects last several months; sun protection, gentle handling, and top-ups every few months maintain them.
A completed Rejuran i course of about 3 sessions typically holds for several months, with each individual under-eye boost most noticeable for roughly 2 to 4 months. Because it is a regenerative polynucleotide booster, results fade gradually rather than stopping suddenly. Our Rejuran page explains how the eye-area course is planned.
Rejuran i is the polynucleotide booster tailored for the delicate skin around the eyes, improving thin, crepey, tired-looking periocular skin. It repairs skin quality and fine texture rather than filling a hollow. Because it targets skin thickness and resilience, its several-month result reflects a skin-repair effect built over a course of sessions.
A single session begins the repair but does not build the full collagen reserve, so its standalone effect softens within about 2 to 4 months. Rejuran i is designed as a course of roughly 3 sessions, where each visit compounds the last. The cumulative collagen from a full course is what carries the several-month improvement in eye-area skin.
No, Rejuran i is not a one-time fix; it improves eye-area skin quality for several months before gradually fading. Natural ageing and collagen turnover continue over time, so periodic maintenance keeps the delicate skin looking its best. Many patients pair it with a longer-lasting collagen option such as Juvelook for the wider face.
Most patients maintain their result with a top-up session every few months, usually a single visit after the initial course. The exact interval depends on your skin and how quickly the effect fades. Pairing it with a consistent skin care routine and diligent eye-area sun protection helps stretch the time between visits.
They do different jobs, so longevity is not directly comparable. Rejuran i repairs skin quality for several months, while cross-linked hyaluronic acid filler adds contour that can last up to about a year. If your concern is a hollow tear-trough rather than skin texture, our injectable fillers page explains how volumising products work and last.
The fullest effect usually appears 4 to 8 weeks after the final session, once new collagen has matured in the eye area. Improvement is gradual throughout the course, with many patients noticing smoother, more resilient under-eye skin after the second session. Clinical periocular studies measured elasticity and roughness gains across the 3-session protocol.
Longevity depends on how many sessions you complete, baseline skin thinness, age, sun exposure, and eye-rubbing habits. Completing a full course of about 3 sessions and protecting the eye area from UV typically extends the benefit. Very thin or sun-damaged eye-area skin may fade faster and can benefit from an added session in the plan.
No, the brief downtime does not change longevity. Small bumps and mild redness under the eyes typically settle within one to two days, and occasional light bruising can occur because eye-area skin is delicate. Longevity depends on collagen build-up from the course and natural skin turnover, not on the short recovery afterward.
Yes, Rejuran i is often combined with under-eye hydration boosters or, where a hollow exists, with filler, sequenced safely by your doctor for complementary results. Many patients pair skin repair with a glow-focused booster. Our glass-skin booster page explains a hydration-led option that fits alongside Rejuran i.
Results fade gradually, not suddenly, because the polynucleotide scaffold is resorbed slowly and the new collagen turns over across months. You will usually notice a slow softening of thickness and smoothness rather than an abrupt loss. This gentle taper is why a maintenance session before the effect fully fades keeps the eye area looking consistent.
Yes, Rejuran i has a well-documented safety profile and is designed for repeat maintenance, with the purified polynucleotide processed to remove proteins for biocompatibility. Side effects are usually limited to temporary redness or small bumps. Your doctor reviews your history, including any salmon allergy, before each course to keep repeat eye-area treatment safe.
A full course of about 3 sessions spaced 2 to 4 weeks apart usually gives the most durable outcome, as each session compounds the collagen benefit in delicate skin. Patients with very thin eye-area skin may gain from an extra session. Your doctor recommends the ideal number at consultation based on your skin and goals.
Rejuran i can soften dark circles caused by thin, crepey skin by thickening and improving that skin over several months, but it does not last as a fix for circles caused by pigment or a hollow. Your doctor identifies your dark-circle type at consultation and advises whether skin repair or another approach suits your case.
For a single Rejuran i boost you need only one to two days, covering consultation and treatment with minimal downtime. To build the longest-lasting result you would complete a course, so your team can schedule sessions across a longer stay or plan follow-ups for a return trip. Our English team coordinates timing around your travel.
Yes, flying the next day is generally fine, and international patients can have remote check-ins in English as the eye-area result settles and later fades. Your team advises when maintenance is due and can plan it for a return trip, alongside related care such as glass-skin boosters. Your treatment notes stay on file.
| Rejuran i (eye PN) | Under-eye HA booster | Under-eye HA filler | |
|---|---|---|---|
| Active / mechanism | Polynucleotide (PN, salmon DNA), skin-healing repair | Hyaluronic acid micro-droplets, hydration | Cross-linked hyaluronic acid, structural volume |
| Main goal | Thin, crepey eye-area skin quality | Hydration and light glow under the eyes | Filling a hollow or tear-trough contour |
| Longevity | Several months per course, boost felt 2 to 4 months | Several months, varies | Often up to about a year, varies |
| Onset of results | Gradual over weeks across about 3 sessions | Hydration within days, refines over weeks | Immediate contour, settles over 2 weeks |
| Downtime | Tiny bumps and mild redness for a day or two | Minimal, brief redness | Possible swelling or bruising for days |
| Sessions to peak | Usually a course of about 3 | Often a short series | Often a single session, topped up later |
| Maintenance rhythm | Every few months to sustain | Periodic, varies | Longer interval between top-ups |
| Cost context | Consultation-led; depends on sessions | Consultation-led; depends on product | Consultation-led; depends on product and volume |
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