Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Re2o is an hADM extracellular-matrix booster, roughly 80% collagen; its glass-skin glow builds over about 3 sessions and typically holds for several months.
Re2o results in Korea usually last several months per course. Because Re2o is a human acellular dermal matrix (hADM) skin booster, refinement to texture, pores, and glow builds gradually over about 3 sessions spaced 2 to 4 weeks apart. The fullest effect shows after the course, and most patients keep it with a top-up every 6 to 12 months.
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Re2o is a skin-quality booster built on the extracellular matrix (ECM), the natural scaffold that holds skin cells together. It is a human acellular dermal matrix (hADM) product, roughly 80% collagen with smaller amounts of elastin and glycosaminoglycans, injected into the upper dermis to refine texture, minimise the look of pores, and build the dewy glass-skin glow. Unlike a contour filler that adds instant volume, Re2o improves skin quality, so its effect develops over a course rather than appearing in one visit. It is not an exosome therapy and not a volumising filler.
How long it lasts depends on how many sessions you complete and your own skin turnover. A typical course of about 3 sessions produces refined, glowing skin that generally holds for several months. Because the matrix is gradually integrated and remodelled with your own tissue, results soften slowly over time rather than stopping abruptly. Most patients maintain the look with a top-up every 6 to 12 months, adjusted to how their skin behaves.
Reberry Clinic is a dermatology clinic that treats international patients across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport) with English-speaking support. The clinic’s doctors match Re2o to your skin thickness and explain realistic duration honestly. You can read more on our glass-skin booster page.
Re2o injects a human acellular dermal matrix booster into the upper dermis, where its collagen-rich matrix integrates with your own skin structure rather than only stimulating collagen indirectly. Over the weeks after each session, the matrix supports fibroblast activity and the skin looks smoother, firmer, and more even. Because it is made of natural structural components, the body gradually remodels and turns over the material through normal tissue renewal, so results are not permanent; they soften over months. This is why a course of about 3 sessions, not a single visit, gives the fullest and longest-lasting refinement.
Maintenance works by topping up before the previous course fully fades, which keeps skin consistent and usually needs fewer sessions than starting over. Many patients pair Re2o with hydration-led glow treatments or a regenerative option for complementary effects, planned by a doctor. You can read about a polynucleotide alternative on our Rejuran Healer page, and about the broader glow approach on our glass-skin page. Sun protection and good skincare help results hold closer to their full duration.
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The hADM booster is placed across the target area in 1 session of about 15 to 20 minutes; some refinement is often visible within days.
Over the next 2 to 4 weeks, texture and glow improve as the matrix integrates, before the 2nd session builds on it.
After about 3 sessions spaced 2 to 4 weeks apart, skin reaches its fullest, most even glass-skin glow.
For several months the refinement stays largely consistent as the matrix supports your own skin structure.
A top-up every 6 to 12 months, often using fewer sessions than the first course, keeps the result even.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
An English-language consultation assesses your skin thickness and texture, discusses goals, and confirms whether standard Re2o or lighter Re2o Fine suits you and how long results should last.
After topical numbing for about 20 to 30 minutes, the micro-injection session itself takes about 15 to 20 minutes, with the visit under an hour.
A full plan is usually about 3 sessions spaced 2 to 4 weeks apart, easy to schedule across a Seoul trip or a return visit.
Some refinement often shows within days, with texture and glow building over weeks and the fullest effect after the course.
Results commonly last several months; sun protection, gentle skincare, and top-ups every 6 to 12 months help maintain them.
A course of Re2o usually lasts several months, with the fullest glass-skin glow appearing after about 3 sessions spaced 2 to 4 weeks apart. Because the hADM matrix is gradually remodelled with your own skin, results soften slowly rather than stopping. Most patients maintain them with a top-up every 6 to 12 months, as explained on our glass-skin booster page.
Re2o is a human acellular dermal matrix (hADM) booster, roughly 80% collagen with smaller amounts of elastin and glycosaminoglycans. Injected into the upper dermis, it replenishes real extracellular matrix to refine texture, pores, and glow. It is a skin-quality booster, not a contour filler and not an exosome therapy, which shapes how long and how gradually it works.
Most patients need about 3 sessions spaced 2 to 4 weeks apart for the fullest, longest-lasting refinement, though some benefit from one or two more. A single injection gives partial results because the effect builds over a course. The clinic’s doctors confirm your ideal number at consultation based on your skin thickness and concerns.
Re2o involves only mild stinging during the fine micro-injections, managed with topical numbing applied for about 20 to 30 minutes beforehand. Downtime is minimal, with tiny bumps and slight redness for a day or two as the product settles. You can usually return to normal activity the same day, avoiding heat and heavy exercise briefly.
No, Re2o is a human acellular dermal matrix skin-quality booster, not an exosome therapy and not a volumising contour filler. It refines texture, pores, and glow rather than reshaping contours, which is why its effect builds over a course. If you want structural volume instead, our injectable fillers page explains how contour fillers differ.
Some refinement often shows within days, but the true smoothing and glow build over several weeks and reach their fullest after the course of about 3 sessions. Judging on day one can mislead. The clinic maps the expected timeline at consultation so you know when to assess your settled result and plan maintenance.
Yes, completing the full course, protecting skin from sun, and using gentle skincare all help results hold closer to their full duration. Topping up before the course fully fades keeps the glow even. Some patients pair Re2o with a regenerative option such as Rejuran Healer for added support, planned by a doctor.
Re2o fades gradually, so skin slowly returns toward its previous texture over months rather than changing overnight; it is not damaged in normal use. You will not suddenly look different. A top-up before full fade keeps refinement consistent, and many patients maintain the glow with a session every 6 to 12 months.
Re2o Fine uses a lighter formulation placed more superficially, suited to thin or delicate skin, while standard Re2o sits slightly deeper for firmness and structure. Both share the same hADM building blocks and similar overall longevity. A doctor chooses between them based on your skin thickness, as outlined on our glass-skin booster page.
Yes, Re2o is injected beneath the surface and does not rely on light or heat, so it suits a wide range of skin tones with similar longevity. Clinical studies report a favourable safety profile with no serious adverse events. Your suitability and product choice are confirmed during assessment by the clinic’s doctors before treatment.
Aftercare supports longevity: keep the area clean, skip makeup for the day, and avoid saunas, intense exercise, and alcohol for a couple of days. Consistent sun protection and hydration afterward help results hold closer to their full duration. The team provides clear written guidance, including support after you travel home from Seoul.
Yes, a doctor can sequence Re2o safely with lasers, energy lifting, or other boosters for complementary effects. Many patients pair it with a hydration or repair booster for a fuller glow. You can read about a polynucleotide option on our Rejuran Healer page to understand how they differ and combine.
Pricing should be clear before treatment, since cost depends on how many sessions you plan and the area treated. Reberry Clinic explains the details at consultation rather than adding surprise charges. Because plans are personalised to your skin thickness and goals, a short consultation is the best way to understand what your Re2o course will involve.
For a single session you need only one to two days, covering consultation and treatment with minimal downtime. If you want part of a course, the team can schedule sessions across a longer stay or plan follow-ups for a return trip. Our English-speaking staff coordinate timing around your travel plans.
Yes, flying soon after Re2o is generally fine, often the next day, because it is a minimally invasive injectable with only minor swelling or tiny bumps. Stay hydrated during the flight and avoid pressing the treated skin. If you had extensive treatment, your doctor will advise any specific timing before you travel home from Seoul.
International patients receive a written plan showing expected duration, so you know roughly when a top-up may be due before results fully fade. You can have remote check-ins in English and time maintenance to a future Seoul trip. Your treatment notes are kept on file, and related care is described on our glass-skin page.
| Re2o (hADM ECM) | Rejuran (PN) | Skin booster (HA) | |
|---|---|---|---|
| Active / mechanism | Human acellular dermal matrix, collagen-rich scaffold | Polynucleotide from salmon DNA, tissue repair | Hyaluronic acid micro-droplets, hydration |
| Best for | Texture, pores, firmness, glass-skin glow | Repair, elasticity, healing support | Deep, lasting hydration and glow |
| Results timeline | Often visible after 1 session, builds over weeks | Builds over a course of sessions | Hydration within days, refines over weeks |
| Longevity | Several months, maintained with top-ups | Several months, maintained with top-ups | Several months, varies with area |
| Sessions | Usually a course of about 3 | Usually a course of about 3 to 4 | Often a short series |
| Downtime | Tiny bumps and redness for a day or two | Tiny bumps and redness for a day or two | Minimal, brief redness |
| Cost context | Consultation-led; depends on sessions and area | Consultation-led; depends on sessions and area | Consultation-led; depends on product and area |
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