Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Results build over a 3-session course spaced 2 to 4 weeks apart and typically last 6 to 12 months, with maintenance often planned around the 12-month mark.
Rejuran HB results build over a course of about three sessions spaced 2 to 4 weeks apart, and once complete the effect typically lasts around 6 to 12 months. Because it stimulates your own skin rather than adding lasting volume, it is not a one-time fix; many patients in Korea book a maintenance session near the 12-month mark.
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Rejuran HB is an injectable skin booster that combines polynucleotides (PN) — long-chain fragments of purified salmon DNA, in the same family as PDRN — with hyaluronic acid (HA). The polynucleotides support the skin’s own repair processes, while the hyaluronic acid adds immediate hydration and plumpness. Because the treatment works by prompting your skin to renew rather than by placing a long-lasting filler, its effect is cumulative and time-limited, which is exactly why duration is the most common question.
The immediate HA hydration can be visible within days, but the deeper improvement in skin quality — texture, fine lines, and firmness — develops over weeks as the polynucleotides do their work. This is why a single session is rarely the full story and why a short course is standard. Understanding this build-then-fade pattern is the key to setting realistic expectations about how long results last.
Reberry Clinic is a dermatology clinic offering English-language consultations across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport), including a site near the airport for travellers. The clinic’s doctors tailor the number and spacing of sessions to your skin. For the full treatment detail, see our Rejuran Healer page.
The active ingredient in Rejuran HB is polynucleotide (PN), a purified salmon-DNA polymer that acts as a biostimulator: rather than filling space, it supports fibroblast activity, hydration, and the skin’s repair environment. Studies of polynucleotides report gradual improvement in skin elasticity, texture, and fine lines over a course of sessions, which is why the benefit accumulates and then gradually tapers rather than switching on and off.
The hyaluronic acid in the HB formulation adds a hydrating, plumping component on top of the polynucleotide effect, but HA itself is metabolised over months. The combined result is an early hydration boost followed by a slower quality improvement, with total duration commonly in the 6 to 12 month range. Because this is biostimulation, not permanent volume, maintenance keeps the effect going. Reberry Clinic performs the treatment with the clinic’s doctors, and a booster like this is often paired with lifting on our Ultherapy Prime page.
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The first of about 3 sessions delivers polynucleotides and hyaluronic acid via fine micro-injections; the HA hydration may be visible within 3 to 7 days.
Repeated at 2 to 4 week intervals, each session adds to the last, so the skin-quality benefit accumulates across roughly 6 to 12 weeks total.
Improvement in texture, fine lines, and firmness typically peaks around 4 to 8 weeks after the final session as the polynucleotides finish their work.
Once the course is complete, results hold on a plateau for several months, commonly within a 6 to 12 month window depending on the individual.
Because this is biostimulation rather than permanent volume, the effect fades slowly rather than disappearing at once, usually noticeable after 6 months or more.
Many patients schedule a single maintenance session around the 12-month mark to top up the improvement before it declines significantly.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
An English-language consultation with the clinic’s doctors reviews your skin quality and goals and confirms whether a course of about 3 sessions suits you. Cost is discussed here, as it depends on session count and areas.
Each session takes roughly 20 to 40 minutes including numbing; fine micro-injections deliver the polynucleotide and hyaluronic acid across the treatment area.
The full course of 3 sessions spans about 6 to 12 weeks with 2 to 4 week gaps, so international patients often align one or two sessions with separate Seoul visits.
Early hydration may show within days, while the deeper skin-quality improvement peaks around 4 to 8 weeks after the last session.
Results commonly last 6 to 12 months; protect skin from sun, stay hydrated, and the clinic can advise on maintenance timing by email after you return home.
After completing the course of about three sessions, results typically last around 6 to 12 months. Because Rejuran HB stimulates your own skin rather than adding permanent volume, the effect builds then tapers gradually. Many patients plan a maintenance session near 12 months; see our Rejuran Healer page for detail.
Most people have a course of about three sessions spaced 2 to 4 weeks apart, because the benefit accumulates with each visit. A single session gives mainly early hydration, while the full course delivers the deeper improvement detailed on our Rejuran Healer page, holding for 6 to 12 months.
The hyaluronic acid can give visible hydration within 3 to 7 days, but the deeper improvement in texture and fine lines develops over weeks. Results usually peak around 4 to 8 weeks after your final session as the polynucleotides finish supporting skin renewal, then hold on a plateau for months.
No, it is not a one-time fix. It works by stimulating your skin’s own renewal, so the effect is cumulative and time-limited, commonly lasting 6 to 12 months. Skin continues to age naturally afterward, which is why a maintenance session is usually planned rather than expecting a single course to last indefinitely.
Completing the full course, your age and baseline skin quality, sun protection, hydration, and lifestyle factors such as smoking and sleep all influence duration. Younger, well-protected skin often holds results toward the longer end. The clinic’s doctors can advise how to preserve your outcome between sessions.
Discomfort is usually mild. A numbing cream is applied first, and the treatment uses fine micro-injections, so most people feel small pinches rather than significant pain. Each session takes roughly 20 to 40 minutes including numbing, and any tenderness typically settles within a day or two after your visit.
Downtime is generally minor: small injection bumps, mild redness, or occasional tiny bruises that usually settle within a few days. There are no stitches, so most patients return to normal activities quickly. This makes it manageable during a trip, though bruising can vary between individuals and areas.
Yes, it is often combined with lifting or collagen-stimulating treatments to improve both quality and firmness. Sequencing and spacing matter, so the clinic’s doctors plan the order. A common pairing is a booster with ultrasound lifting; see our Ultherapy Prime page for that option.
A filler adds volume that lasts as long as the material persists, while Rejuran HB is a biostimulator that improves skin quality by supporting renewal. Its main role is skin repair, not contour, which is why duration is a 6 to 12 month range; for volume, see our Injectable Fillers page.
Rejuran HB is a polynucleotide booster focused on skin quality and hydration, while Juvelook is a PDLLA collagen stimulator focused on firmness and glow that tends to last longer. They target different goals and are sometimes used together. Learn about the biostimulator on our Juvelook page.
Common effects are temporary redness, small injection bumps, mild swelling, and occasional bruising that resolve within days. Because the polynucleotide is salmon-derived, anyone with a fish or salmon allergy should tell the clinic. Serious reactions are uncommon, and the clinic’s doctors review your history to reduce risk before treatment.
Keep the skin clean, well hydrated, and sun-protected, and avoid intense heat such as saunas and heavy exercise for a day or two. Good aftercare supports the polynucleotide effect and can be paired with a glow-focused plan on our Glass Facial Skin page.
Each session is a short outpatient visit of roughly 20 to 40 minutes with minimal downtime, so no extra recovery days are usually needed. The challenge for foreigners is the multi-week course, so many complete one or two sessions per trip or plan maintenance around future Seoul visits.
Generally yes, since there are no incisions and downtime is minor. Mild redness or small bumps settle quickly and do not prevent flying. If you bruise easily, mention it at consultation and consider spacing the session a day or two before departure so any marks can fade comfortably.
Reberry Clinic offers English-language follow-up by message after you return home, so you can track how your skin holds and time a maintenance session, often near 12 months, around a future trip. The team can also advise whether to combine maintenance with other treatments during your next Seoul visit.
These skin treatments differ in mechanism and duration, so the right choice depends on whether you want repair-led skin quality, collagen stimulation, or pure hydration.
| Rejuran HB | Juvelook | HA skin booster | |
|---|---|---|---|
| Mechanism | Polynucleotide biostimulator plus hyaluronic acid | PDLLA collagen stimulator | Hyaluronic acid hydration |
| Main goal | Skin quality, hydration, fine lines | Collagen build, firmness, glow | Immediate hydration and plumpness |
| Course | Usually about 3 sessions, 2 to 4 weeks apart | Usually a short series of sessions | Often a short series of sessions |
| When results peak | About 4 to 8 weeks after final session | Gradually over 2 to 3 months | Within days for hydration |
| Typical duration | Around 6 to 12 months | Longer, months and up, individual | Shorter, often a few months |
| Maintenance | Often near the 12-month mark | Periodic, individualised | More frequent top-ups |
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