Rejuran Healer treatment
Our Expertise

How Many Sessions of Rejuran i You Need in Korea

Skin

Most under-eye patients start with a course of 3 to 4 Rejuran i sessions spaced 2 to 4 weeks apart, then maintain every 6 to 12 months.

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Most people need an initial course of 3 to 4 Rejuran i sessions for the under-eye area, spaced 2 to 4 weeks apart, then maintenance every 6 to 12 months. The number depends on how thin, crepey, or dark the skin is, so at Reberry Clinic in Korea the plan is confirmed after an in-person assessment of your under-eye skin.

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What is Rejuran i?

Rejuran i is the under-eye version of the Rejuran polynucleotide skin booster, formulated for the thin, delicate skin around the eyes. Like the classic treatment, it uses polynucleotides (PN), purified salmon-derived DNA fragments, but it is designed for careful placement in the periorbital area to improve skin quality, texture, and resilience. It targets crepey, thin under-eye skin and fine lines rather than adding volume, so results build gradually across a course of sessions.

The under-eye area is why the session plan is important. Skin here is among the thinnest on the face, so improvements in firmness, smoothness, and tone accumulate over repeated treatments rather than appearing after one. Most protocols recommend an initial course of 3 to 4 sessions, spaced 2 to 4 weeks apart, with the exact number depending on how thin, crepey, or shadowed the skin is. Under-eye darkness that is caused by skin quality may soften over the course, though pigment- or hollow-based shadows behave differently.

Reberry Clinic is a dermatology clinic serving international patients across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport), with English-speaking support. The clinic’s doctors assess your under-eye skin and set a realistic session plan. You can read more about the polynucleotide family on our Rejuran Healer page.

Rejuran Healer treatment

Why Rejuran i needs a course of sessions

Rejuran i delivers polynucleotides (PN/PDRN) into the delicate under-eye dermis, where they support fibroblast activity and hydration. Because the skin here is thin and improvements are structural rather than a cosmetic fill, the area needs repeated, gentle exposure over weeks to show a visible change in texture and firmness, which is why 3 to 4 sessions are standard for the under-eye.

The 2 to 4 week interval lets the fragile periorbital skin recover and respond before the next dose. Because Rejuran i improves skin quality rather than replacing lost volume, the clinic’s doctors may discuss pairing it with other approaches when hollowing is a factor; for volume-related shadows, injectable fillers address a different cause. Careful sequencing keeps the sensitive area safe across a course.

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Our Clinics

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Key Benefits

Key Benefits of a Full Rejuran i Course

Rejuran Healer treatment
How It Works

How the Rejuran i Session Plan Works

Rejuran Healer treatment
Assessment

In about 10 to 15 minutes, the clinic’s doctors examine your under-eye skin thickness, texture, and shadowing to set how many of the usual 3 to 4 sessions you need.

Polynucleotides are placed carefully across the under-eye area after numbing cream is applied for roughly 20 to 30 minutes.

Sessions repeat at 2 to 4 week intervals so the thin skin recovers between each of the 3 to 4 treatments.

After 3 to 4 sessions over about 6 to 12 weeks, improvement in under-eye texture and firmness is most visible.

A top-up every 6 to 12 months helps sustain results, adjusted to how your under-eye skin holds the effect.

Comparison

Rejuran i vs Other Under-Eye Options: Session Needs

Rejuran Healer treatment

Which Should You Choose?

Why It Suits You

Before & After

Real Before & After Results

See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.

Rejuran Healer before and after result 1 at Reberry Clinic
Rejuran Healer — result 1
Rejuran Healer before and after result 2 at Reberry Clinic
Rejuran Healer — result 2
Rejuran Healer before and after result 3 at Reberry Clinic
Rejuran Healer — result 3
Rejuran Healer before and after result 4 at Reberry Clinic
Rejuran Healer — result 4
Results vary by individual. Photos taken under standardized clinical lighting at Reberry Clinic during the 90–180 day post-treatment window.
The Process

Your Rejuran i Journey in Korea

Consultation

An English-language consultation assesses your under-eye skin and confirms how many of the usual 3 to 4 sessions suit your goals.

After numbing for about 20 to 30 minutes, each session takes roughly 10 to 20 minutes of careful placement around the eyes.

The initial course of 3 to 4 sessions runs over about 6 to 12 weeks, spaced 2 to 4 weeks apart.

Under-eye texture and firmness improve gradually, becoming clearest a few weeks after the final session.

A maintenance session every 6 to 12 months helps sustain results; gentle care and sun protection support the delicate area between visits.

Good Candidates

Cautions & Contraindications

Scientific Evidence

Clinical evidence for polynucleotide treatment of the periorbital area supports a repeated-session approach, with outcomes accumulating across a course. In a randomized, split-face trial of 27 subjects, polynucleotide injections given 3 times at 2-week intervals improved periocular skin elasticity, hydration, roughness, and pore volume, with the polynucleotide side showing a higher rate of improvement than hyaluronic acid. A 2024 survey of Korean aesthetic medicine specialists reported that most deliver injectable polynucleotide as a multi-session course, typically 3 to 4 treatments spaced 2 to 4 weeks apart with periodic maintenance, reflecting the cumulative effect. A 2025 systematic review across multiple studies likewise found measurable improvement in skin quality with repeated polynucleotide sessions and a favorable safety profile in the delicate facial areas.
  • Kwon TR, Han SW, Yeo IK, et al. Comparison of the effects of polynucleotide and hyaluronic acid fillers on periocular rejuvenation: a randomized, double-blind, split-face trial. J Dermatolog Treat. 2022;33(1):254-260. doi:10.1080/09546634.2020.1748857
  • Rho NK, Han KH, Kim HS, et al. A survey on the cosmetic use of injectable polynucleotide: the pattern of practice among Korean dermatologists. J Cosmet Dermatol. 2024;23(9):2882-2890. doi:10.1111/jocd.16125
  • Lampridou S, Georgiou E, Goula K, et al. The effectiveness of polynucleotides in esthetic medicine: a systematic review. J Cosmet Dermatol. 2025;24(1):e16721. doi:10.1111/jocd.16721
  • Lee KWA, Chan LKW, Hung LC, et al. Real-world clinical practice on skin rejuvenation among Korean physicians: survey-based results. Ann Dermatol. 2024;36(6):345-356. doi:10.5021/ad.24.167
  • Rho NK, Gil YC, Kim HJ, et al. Clinical efficacy and safety of a highly purified polynucleotide for dry and chapped lips: a prospective, multicenter study. J Cosmet Dermatol. 2025;24(6):e70224. doi:10.1111/jocd.70224
  • Cavallini M, Papagni M, Ryu HS, et al. Prospective multicentre real-world study of a bioregenerative combination therapy with polynucleotide high-purification technology and hyaluronic acid for atrophic facial acne scars. Cosmetics. 2026;13(1):1. doi:10.3390/cosmetics13010001
FAQ

Frequently Asked Questions

How many sessions of Rejuran i do I need in Korea?

Most people need an initial course of 3 to 4 under-eye sessions spaced 2 to 4 weeks apart, because improvements in the thin periorbital skin build cumulatively. Thinner or more crepey skin may need the higher end. The clinic’s doctors confirm your number after assessment, as explained on our Rejuran Healer page, rather than fixing it in advance.

A single under-eye session gives only a subtle result, because the thin periorbital skin needs repeated exposure over weeks to show visible change. That is why 3 to 4 sessions are standard, each spaced 2 to 4 weeks apart. The course, not one treatment, is what improves under-eye texture and firmness meaningfully over time.

Sessions are usually spaced 2 to 4 weeks apart, giving the delicate under-eye skin time to recover before the next dose. Spacing them too closely offers little extra benefit for such thin skin, while long gaps slow progress. Your doctor sets the interval within this range based on how the area responds.

Rejuran i can soften under-eye darkness that stems from thin, dull, or crepey skin quality, improving over the 3 to 4 session course. However, darkness caused mainly by pigment or hollowing responds differently; hollow-related shadows may need injectable fillers instead. A consultation identifies the cause so the right plan is chosen.

Most patients feel only mild discomfort, since numbing cream is applied for about 20 to 30 minutes before each session. You may notice small pinches as polynucleotides are placed around the eyes. Any stinging is brief, and the practitioner works carefully in the sensitive area to keep each session as comfortable as possible.

Downtime is minimal; expect brief redness, small bumps, or slight swelling around the eyes for about 1 to 3 days, which settle before your next session. Occasional minor bruising is possible in this delicate area. Because the 2 to 4 week interval allows recovery, downtime rarely disrupts a course or a short trip.

Results build gradually, becoming clearest a few weeks after your final session as the skin completes its repair. Many notice smoother, less crepey under-eye skin partway through the 3 to 4 session course. Because the effect is cumulative, judging after the full course gives a better picture than after a single treatment.

After completing the initial course, under-eye improvements commonly last several months to around a year, depending on skin and lifestyle. A maintenance session every 6 to 12 months helps sustain the effect. Because Rejuran i supports skin quality rather than being a one-time fix, gentle top-ups keep the periorbital area consistent over time.

After the initial 3 to 4 session course, most people maintain results with a single under-eye session every 6 to 12 months, adjusted to how your skin holds the effect. Your doctor sets a realistic rhythm at review, as outlined on our Rejuran Healer page. This gentle schedule fits periodic visits to Seoul.

Yes, Rejuran i is often planned alongside other skin-quality treatments, and the clinic’s doctors sequence them so they complement the delicate eye area. For overall glow it may pair with a skin care routine, while hollowing may be addressed separately. Combining is planned at consultation so timing and session counts stay safe.

Expect mild redness, small bumps, slight swelling, or tenderness around the eyes for about 1 to 3 days, which resolve on their own. Minor bruising can occur in this delicate area. Serious reactions are uncommon with careful technique, so most patients continue their course and plans without needing extra recovery days.

Keep the area clean, avoid rubbing the eyes, skip heavy eye makeup for about a day, and apply sunscreen daily. Gentle hydration supports healing between your 2 to 4 week intervals. Following the clinic’s written aftercare and a suitable skin-quality routine helps maintain the improvement Rejuran i builds.

Rejuran i improves under-eye skin quality using polynucleotides over a course, whereas filler replaces lost volume in a single placement to lift a hollow. They solve different causes of tired-looking eyes and are sometimes combined. If your shadow is volume-related, the clinic may suggest injectable fillers for that specific concern.

Each Rejuran i session needs only a day, including a short consultation, since downtime is minimal and redness settles within a few days. Because sessions are 2 to 4 weeks apart, most international patients complete part of the course per trip. Our English team coordinates timing so under-eye visits fit your schedule.

Yes, flying soon after a session is generally fine, often the same day, because the treatment is minimally invasive with only brief redness or small bumps. Avoid rubbing the eyes, keep the area clean, and apply sunscreen on arrival. Any specific guidance for your plan is given before you travel back.

You can complete part of the initial under-eye course per trip and return for the remaining sessions, since the 2 to 4 week spacing allows flexibility. English-language remote check-ins help review progress and plan your next visit. Your treatment notes stay on file so any doctor at our Seoul locations can continue your plan.

Rejuran iUnder-eye HA fillerSkin booster (HA)
MechanismPolynucleotide (salmon DNA) skin repairHyaluronic acid adds volumeHyaluronic acid hydration
Best forThin, crepey under-eye skin qualityHollow, volume-related shadowsSurface hydration and glow
Typical initial course3 to 4 sessions1 session, reviewed later3 or more sessions
Session interval2 to 4 weeks apartSingle placement, top-up later2 to 4 weeks apart
Pain / comfortMild; numbing cream usedMild; numbing cream usedMild; numbing cream used
DowntimeBrief redness or small bumps for 1 to 3 daysPossible swelling or bruising for daysMinimal, hours to a day
MaintenanceEvery 6 to 12 monthsOften 9 to 18 monthsEvery few months
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Our Doctors

Meet the Doctors Behind Reberry Clinic

Your treatment is planned and performed by experienced, MFDS-registered doctors across our Seoul-area clinics, with multilingual support for international patients.

Dr. Yoon-Gon Ryu — Aesthetic Medicine Specialist, Reberry Clinic Gangnam
Gangnam

Dr. Yoon-Gon Ryu

Aesthetic Medicine Specialist

Flagship clinic · KOL for leading lifting & regenerative devices · Featured in Authority Magazine (2026)

Dr. Seung Jae Baek — Medical Director, Reberry Clinic Myeongdong
Myeongdong

Dr. Seung Jae Baek

Medical Director

Multilingual tourist care beside Myeongdong Cathedral

Dr. Sunbeen Kim — Chief Director, Reberry Clinic Incheon Airport
Incheon Airport

Dr. Sunbeen Kim

Chief Director

Fast, effective care 20 minutes from the terminals

Plan your Rejuran i sessions in Korea

Message us on WhatsApp for a free consultation in English and a personalised Rejuran i under-eye session plan.

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