Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Rejuran i is the eye-area polynucleotide developed in Korea; the thin under-eye skin means care matters, and effects are mostly mild, settling within 2 to 3 days.
Rejuran i has a strong safety profile in Korea, where it was developed as the eye-area polynucleotide (PN) for delicate under-eye skin. Reported side effects are mostly mild and temporary, such as injection bumps, redness, swelling or bruising that settle within 2 to 3 days. Because the skin here is thin, safety depends on an experienced doctor, confirmed at consultation.
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Rejuran i has a strong safety record in Korea, where it was developed specifically for the delicate skin around the eyes, and it is widely used to improve under-eye texture, fine lines and dark, tired-looking circles. It is made of polynucleotide (PN), highly purified long-chain DNA fragments derived from salmon, a biocompatible material the body tolerates well. Rather than adding a volume gel, Rejuran i supports the skin’s own repair in a zone where the skin is only around 0.5 mm thick, which is why gentle, precise injection matters. The most frequently reported effects are mild and temporary: small bumps at the injection points, brief redness, mild swelling and occasional bruising that usually settle within 2 to 3 days.
Because the under-eye area is thinner and has more fine blood vessels than the cheeks, bruising is a little more common here, and technique matters even more than for standard face treatment. Safety depends on sterile technique, correct shallow depth, and honest screening of your medical history. A small number of people should be cautious or avoid treatment, including those allergic to fish or salmon-derived products, and the clinic asks about this at consultation. Rejuran i is delivered as a course of typically 3 to 4 sessions, so the doctor also monitors how the delicate area responds over time.
Reberry Clinic is a dermatology clinic where injectables are performed by the clinic’s doctors, and it serves international patients in Korea with English-speaking support across its Seoul locations and near Incheon Airport. The team reviews your suitability before any Rejuran under-eye session, so safety is assessed for your individual skin rather than assumed.
Rejuran i is an eye-area polynucleotide (PN) formulation: long chains derived from salmon DNA that act as a biostimulator, tuned for the thin skin around the eyes. Instead of adding volume, it supports hydration, elasticity and the skin’s natural repair over the 4 to 8 weeks after each session. Because the material is purified to a high degree, removing most protein content, allergic and serious adverse reactions are uncommon; and because it is not a volumizing gel, it does not carry the vascular-occlusion concerns that apply to volumizing filler placed under the eye. This mechanism is a key reason the safety profile is favorable when treatment is performed correctly in this delicate zone.
That said, Rejuran i is different from an under-eye HA tear-trough filler, which adds volume and carries its own precautions, or a collagen-building approach; each has its own safety considerations, so the right choice depends on your under-eye concern. The clinic’s doctors explain these differences and screen your history, so the treatment selected is both appropriate and safe for you rather than chosen on popularity alone.
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The doctor reviews your history, allergies and under-eye skin, checking against the 5 main contraindications before treatment.
Anyone with a fish or salmon allergy is flagged, since Rejuran i is salmon-derived; 1 disclosed allergy can change the plan.
The doctor maps the thin under-eye skin, only around 0.5 mm thick, so injection points are placed precisely and shallowly.
Injections use sterile, single-use needles at the correct depth, spacing the typical course of 3 to 4 sessions to monitor response.
You receive written aftercare, and the doctor reviews healing within the first 3 days so any bruising or rare delayed effect is addressed early.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
An English-language consultation screens your history and allergies and confirms whether Rejuran i is suitable for your under-eye skin.
After numbing and antisepsis, the doctor injects the delicate area precisely; a session commonly takes around 20 to 30 minutes.
A full course is typically 3 to 4 sessions spaced 2 to 4 weeks apart, so the doctor monitors the area over time.
Under-eye texture improves gradually across the course; temporary bumps, redness or bruising settle within 2 to 3 days.
Results are maintained with periodic top-ups every 6 to 12 months; written aftercare and follow-up support recovery, including from abroad.
Rejuran i has a strong safety record in Korea, where it was developed as the eye-area polynucleotide, and is widely used for under-eye texture and fine lines. Reported effects are mostly mild and temporary. Because the area is delicate, safety depends on an experienced doctor, which the team confirms before any Rejuran session.
Rejuran i is a polynucleotide (PN) formulation tuned for the thin skin around the eyes, while standard Rejuran targets overall facial skin quality. Both are highly purified salmon-derived polynucleotide. The eye-area version is placed shallowly and precisely because under-eye skin is only around 0.5 mm thick, so technique matters more here.
The most common effects are mild and temporary: small bumps at the injection points, brief redness, mild swelling and bruising, which can be a little more common here because the skin is thin. These usually settle within 2 to 3 days. Serious reactions are rare, and aftercare helps the temporary bumps and bruising resolve.
People with a known allergy to fish or salmon-derived products should avoid it, and treatment is deferred during pregnancy or breastfeeding and over active infection or eye-area conditions. Those with bleeding disorders or autoimmune conditions need prior review. The clinic’s doctors screen for these during your Rejuran consultation.
Bruising can be a little more common under the eyes because the skin is thinner and has more fine blood vessels than the cheeks. It is still usually mild and settles within 2 to 3 days. Careful technique and post-treatment cooling reduce it, and avoiding blood thinners beforehand, once cleared by your own physician, helps too.
They carry different risks rather than one being universally safer. Rejuran i is not a volume gel, so it avoids the puffiness and vascular concerns that can come with under-eye HA filler, while filler is dissolvable. The most suitable choice depends on whether you need texture or volume, which the doctor assesses.
Most patients feel small stings during injections, and the under-eye area can be more sensitive than the cheeks, but numbing cream makes it manageable. It is normal and not a safety concern. Comfort measures are arranged beforehand, and any unusual or lasting pain after treatment should be reported so the doctor can review it.
Downtime is minimal; small injection bumps, mild redness and some bruising can occur under the eyes and usually settle within 2 to 3 days, with most people resuming normal activities the same day. Avoiding heat, alcohol and strenuous exercise for 24 to 48 hours helps the temporary effects resolve more comfortably.
A standard Rejuran under-eye course is typically 3 to 4 sessions spaced 2 to 4 weeks apart, with periodic maintenance afterwards, and this schedule is well tolerated. Spacing sessions lets the doctor monitor how the delicate area responds, so the number of sessions suits you safely.
Yes, polynucleotide treatment is well tolerated across a wide range of skin tones, and much of the clinical experience and research comes from Korean and Asian skin. Technique is adjusted to your under-eye skin by the clinic’s doctors. Your suitability is confirmed during screening before any plan is finalized.
Yes, Rejuran i is often combined with under-eye filler or gentle laser for dark circles, but sessions are sequenced and spaced by the doctor to keep the delicate area safe and comfortable. Combining is planned rather than done all at once, and it is mapped during your assessment.
Keep the area clean, avoid rubbing or massaging the under-eye unless told to, and skip heat, saunas, alcohol and strenuous exercise for 24 to 48 hours to reduce swelling and bruising. Report any spreading redness, vision changes, severe pain or fever promptly. You receive written aftercare to follow at home.
Yes, Reberry Clinic serves international patients with English-speaking support across its Seoul locations and near Incheon Airport, and screens you in English before treatment. Message us on WhatsApp to discuss your under-eye concern and history so the team can confirm Rejuran i is safe for you and plan your visit.
Most patients fly the same or next day because downtime is minimal, though under-eye bruising may still be visible for a few days before fading. Stay hydrated and avoid extreme heat during travel. You receive a written aftercare plan and can follow up on your Rejuran course remotely from abroad.
Disclose any fish or salmon allergy, blood thinners and supplements, autoimmune conditions, recent eye-area treatments or eye conditions, and whether you are pregnant or breastfeeding. This honest history is what lets the doctor screen safely and tailor the plan for the delicate area. Skipping details is the main avoidable risk, so share everything at consultation.
Under-eye improvements typically build over the course and last around 6 to 12 months before periodic top-ups are considered, and repeat sessions are well tolerated. Because it is a biostimulator rather than a one-time fix, results are maintained rather than permanent. The doctor advises a safe maintenance interval for your skin at review.
A qualitative look at how the safety considerations of Rejuran i differ from a tear-trough volume filler and the standard face formulation.
| Rejuran i | Under-Eye HA Filler | Standard Rejuran | |
|---|---|---|---|
| Material | Eye-area polynucleotide (salmon DNA) | Cross-linked hyaluronic acid gel | Polynucleotide (salmon DNA) |
| Best for | Under-eye texture, fine lines, tired look | Adding volume to a hollow tear trough | Overall facial skin quality |
| Common effects | Injection bumps, redness, some bruising | Swelling, bruising, puffiness if misplaced | Injection bumps, redness, brief bruising |
| Reversible | Not a gel; absorbed naturally | Yes; can be dissolved with hyaluronidase | Not a gel; absorbed naturally |
| Key precaution | Fish or salmon allergy; delicate area | Risk if volume placed too superficially | Fish or salmon allergy |
| Downtime | Little; bruising can last a few days | Little to moderate; bruising possible | Little; settles in 2 to 3 days |
| Sessions | A course of 3 to 4 | Often 1, optional top-up | A course of 3 to 4 |
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