Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
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Rejuran I is the polynucleotide skin booster made specifically for the delicate under-eye area, injected as a course of about 3 sessions spaced 2 to 4 weeks apart.
Rejuran I is a salmon-derived polynucleotide (PN) skin booster formulated for the thin, delicate under-eye area. Micro-injected across roughly 3 sessions spaced 2 to 4 weeks apart, it improves skin thickness, elasticity, hydration, and fine crepey lines, so tired, thin lower-eyelid skin looks fresher. It is a skin-quality treatment, not a filler for hollows.
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Rejuran I is the under-eye version of the Rejuran polynucleotide (PN) family, formulated at a concentration and consistency suited to the thin, mobile skin of the lower eyelid. It is made from purified polynucleotides derived from salmon DNA, and it works by improving the quality of the skin itself, boosting thickness, elasticity, hydration, and microcirculation, rather than adding volume like a hyaluronic acid filler.
The under-eye area is one of the thinnest areas of facial skin, which is why it creases, looks crepey, and shows a dark, tired tone as collagen thins with age. Rejuran I is micro-injected into this area to stimulate fibroblasts and rebuild the skin’s own support, so the surface looks smoother and more resilient. Many patients choose it when their dark circles are driven by thin skin and fine lines rather than by hollowing or pigment.
At Reberry Clinic, Rejuran I is available at our Gangnam (Seoul) location, about 2 minutes from Gangnam Station exit 10, with Dr. Yoongon Ryu and the clinic’s doctors assessing your under-eye concern in English before recommending a plan. It is delivered as a short course, and results build gradually across the sessions.
Rejuran I uses polynucleotides (PN), long chains of purified salmon-derived DNA fragments in the same regenerative family as PDRN. Once micro-injected into the dermis, these fragments act as a biological scaffold and signal, engaging adenosine A2A receptors on fibroblasts, encouraging new type I collagen synthesis, improving microcirculation, and calming inflammation. This is a regenerative mechanism, not a space-filling one, which is why Rejuran I improves the texture, tone, and thickness of thin under-eye skin rather than plumping a hollow. Because it works with your skin’s own biology, change appears gradually over several weeks as collagen remodels, and a short series is used so the effect layers session by session. The under-eye formulation is designed to spread smoothly and sit comfortably in this delicate zone, and a fine needle or cannula plus numbing keeps the procedure tolerable.
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The clinic’s doctors first identify why your under-eye looks dark or tired, since Rejuran I helps thin, crepey skin best and is not the answer for all of the 3 main dark-circle causes.
Topical anaesthetic is applied for about 15 to 20 minutes so the delicate lower-eyelid injections stay comfortable.
Purified polynucleotides are placed into the dermis with a fine needle or cannula in a series of tiny points across the under-eye, taking roughly 10 to 15 minutes.
Over the following 2 to 4 weeks the polynucleotides engage fibroblasts and boost type I collagen, so skin thickness and elasticity improve gradually.
Most plans use about 3 sessions spaced 2 to 4 weeks apart, because the regenerative effect layers with each visit rather than peaking after one.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors examine your under-eye in English and confirm whether thin skin, a hollow, or pigment is driving your dark circles, then explain if Rejuran I is the right fit.
After about 15 to 20 minutes of numbing, the injections take roughly 10 to 15 minutes, so the visit is short.
Rejuran I runs as a course of about 3 sessions spaced 2 to 4 weeks apart, so results build across visits rather than in one.
Skin thickness and tone improve gradually over several weeks as collagen remodels, with the fullest effect after the series is complete.
Results can last several months, and periodic maintenance sessions help sustain them; sun protection and gentle eye-area skincare protect the outcome.
Rejuran I is a salmon-derived polynucleotide skin booster formulated for the under-eye area. It improves the quality of thin, crepey lower-eyelid skin, boosting thickness, elasticity, and tone across a short course of sessions. It is a skin-regenerating treatment, so you can learn more on our Rejuran Healer page.
Rejuran I helps dark circles that come from thin, crepey skin and fine lines, by thickening and firming the under-eye. It does not fill a true hollow or bleach pigment, so its results depend on your cause. At consultation the clinic’s doctors confirm whether thin skin is your main driver before recommending it.
Good candidates are adults whose under-eye looks thin, crepey, or dull rather than hollow. If a tear-trough hollow is the main issue, a different approach may suit you better. A consultation grades your under-eye and confirms fit; you can also explore injectable fillers if volume is the real need.
Discomfort is usually mild because topical numbing cream is applied for about 15 to 20 minutes before the injections. The under-eye is sensitive, so you may feel small pinches, but most patients tolerate it well. A fine needle or cannula is used, and the injection part takes only 10 to 15 minutes.
Downtime is minimal, typically minor swelling, tiny bumps, or occasional pinpoint bruising for a few days. Because the under-eye skin is delicate, small lumps can appear briefly before settling. Most people return to normal activities the same day, which suits travellers on a short Seoul trip.
Most plans use about 3 sessions spaced 2 to 4 weeks apart, because the regenerative polynucleotide effect layers with each visit rather than peaking after one. Your exact number depends on how thin your skin is and how it responds, which your doctor reviews between sessions.
Change is gradual, appearing over several weeks as collagen remodels, with the fullest effect after the series is complete. Unlike a filler, it does not create an instant plumping, so patience is part of the plan. Skin gradually looks thicker, smoother, and less tired across the course.
Results can hold for several months once the course is complete, but it is not a one-time fix; skin ages continually. Periodic maintenance sessions, often a couple of times a year, help sustain the improvement. Your doctor suggests a maintenance rhythm based on your skin at consultation.
Yes, Rejuran I is often planned alongside other treatments; for example, filler for a genuine hollow or a laser for pigment, since each addresses a different dark-circle cause. It also pairs with facial skin boosters. Explore complementary options such as our Rejuran Healer for whole-face skin quality.
Rejuran I is formulated for the delicate under-eye area, while Rejuran Healer targets overall facial skin quality across the cheeks and face. Both use polynucleotides, but the concentration and technique differ for the eye zone. You can compare on our Rejuran Healer page to see which fits your goal.
Rejuran I is widely performed and generally well tolerated when injected by a trained doctor who respects the eye area’s anatomy. Common effects are temporary swelling or small bumps. It is avoided in those with salmon or fish-DNA allergy, active eye-area infection, or during pregnancy, which your doctor screens at consultation.
The most common side effects are temporary and mild: swelling, redness, tiny bumps, or occasional bruising that settle within a few days. Because polynucleotides are highly purified, allergic reactions are uncommon, though anyone with a salmon or fish allergy should tell their doctor. Serious problems are rare with careful technique.
No, Rejuran I regenerates and thickens skin, whereas under-eye filler adds hyaluronic-acid volume to fill a hollow. They solve different problems and are sometimes used together. If your shadow comes from a true tear-trough hollow, ask about injectable fillers instead of, or alongside, Rejuran I.
Keep the area clean, avoid rubbing or heavy makeup for a day, and skip saunas, intense exercise, and alcohol for about 24 to 48 hours. Daily sunscreen and gentle eye-area skincare protect your results. Small bumps usually settle on their own; a supportive skin care routine helps maintain the improvement.
Rejuran I is available at our Gangnam (Seoul) location, about 2 minutes from Gangnam Station exit 10, with Dr. Yoongon Ryu and the clinic’s doctors. The team assesses your under-eye and delivers the treatment in English. Reberry Clinic also operates Myeongdong and Incheon Airport locations for international patients.
For a single session, even 1 to 2 days in Seoul is enough, since the visit is short and downtime is minimal. Because Rejuran I runs as a course of about 3 sessions, many international patients start in Gangnam and continue on return trips, and our English-speaking team helps schedule around your travel.
Yes, flying within a day of Rejuran I is generally fine, as it is a minimally invasive injection. Cabin air is drying, so moisturise gently and avoid rubbing the treated under-eye. If you had noticeable swelling, a cool compress and time usually settle it, and your doctor advises on aftercare while you travel.
International patients can complete a Rejuran I course across one or more trips, and the clinic offers remote check-ins in English between visits so your plan stays on track. You can continue supportive skin care at home, and your treatment notes are kept on file for continuity.
| Rejuran I | Under-Eye HA Filler | Rejuran Healer | |
|---|---|---|---|
| Mechanism | Polynucleotide (PN) skin regeneration, under-eye formula | Hyaluronic acid volume placed under the eye | Polynucleotide (PN) skin regeneration for the face |
| Best for | Thin, crepey, dull lower-eyelid skin and fine lines | Tear-trough hollows that need structural volume | Overall facial skin quality, texture, and firmness |
| What it does | Improves skin thickness, elasticity, and tone | Fills a hollow to reduce shadow | Improves skin quality across cheeks and face |
| Pain / comfort | Mild, done under numbing cream | Mild to moderate, often with cannula | Mild, done under numbing cream |
| Downtime | Minor swelling or tiny bumps for a few days | Possible bruising or puffiness for several days | Minor redness or bumps for a day or two |
| Sessions | A course of about 3, then periodic maintenance | Often 1 session, topped up over time | A course of about 3, then maintenance |
| Cost context | Depends on sessions and area treated | Depends on filler type and volume used | Depends on sessions and area treated |
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