Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
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Rejuran i uses salmon-derived polynucleotides tuned for the thin under-eye zone, where skin can be under 0.5 mm thick, delivered over a short series of sessions spaced about 2 to 4 weeks apart.
Rejuran i is a polynucleotide (PN) skin booster injected around the eyes to improve thin, crepey, dull under-eye skin. Salmon-derived polynucleotides stimulate fibroblasts, boost hydration and microcirculation, and firm delicate skin over about 2 to 3 sessions. At our Incheon Airport (Yeongjongdo) location, it suits travellers seeking under-eye refinement near ICN.
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Rejuran i is the under-eye specific formulation in the Rejuran polynucleotide (PN) family, designed for the delicate skin around the eyes. Where standard Rejuran targets the face broadly, Rejuran i is formulated for the thin, sensitive periorbital zone, where skin is far thinner than on the cheeks and shows crepiness, fine lines, and dullness earlier. It is injected as a series of tiny micro-boluses just beneath the surface to strengthen and hydrate skin from within.
The active ingredient is polynucleotide, a long chain of nucleotides purified from salmon DNA. Rather than adding volume like a filler, Rejuran i works as a biostimulator: it signals your own fibroblasts to produce collagen and elastin, improves microcirculation, and holds moisture in the skin. Over the following weeks the under-eye area typically looks smoother, firmer, and less tired, with better skin quality rather than an inflated look.
At Reberry Clinic, Rejuran i is consultation-led. The clinic’s doctors assess whether your under-eye concern is skin-quality driven (crepiness, fine lines, dullness) and therefore well suited to PN, or whether it is mainly a hollow or shadow that a different approach would address. International patients are supported in English at our Incheon Airport (Yeongjongdo) location, near ICN, which is convenient for a stopover or the start of a Seoul trip.
Rejuran i relies on polynucleotide (PN), a purified salmon-derived DNA fragment, not on hyaluronic acid volume or on heat energy. Once placed in the shallow dermis of the under-eye area, the polynucleotide acts as a biostimulatory scaffold: it stimulates fibroblasts to synthesise new collagen and elastin, enhances local microcirculation, and improves the skin’s ability to retain water. Because periorbital skin can be under 0.5 mm thick, injections are placed superficially and in small amounts, which is why an under-eye specific formulation is used rather than a standard facial one. The effect is gradual and quality-based: over roughly 3 to 6 weeks the skin becomes denser and more elastic, so crepey texture and fine lines soften and the area looks less dull. Because PN improves microcirculation, some bluish under-eye dullness can also look brighter. This is distinct from a filler, which physically fills a hollow; the clinic’s doctors decide at consultation which mechanism your concern needs, and the two are sometimes combined in a staged plan.
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The clinic’s doctors first determine whether your concern is 1 of skin-quality issues (crepiness, fine lines, dullness) suited to PN, or a hollow better addressed differently.
A topical anaesthetic is applied for about 20 to 30 minutes so the delicate periorbital area is comfortable before injection.
Polynucleotide is placed as multiple tiny superficial deposits across the under-eye zone, kept shallow because the skin here can be under 0.5 mm thick.
Over the next 3 to 6 weeks the PN signals fibroblasts to build collagen and elastin, improving density, elasticity, and microcirculation.
Most plans use 2 to 3 sessions spaced about 2 to 4 weeks apart, with results accumulating across the course rather than after one visit.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors assess your under-eye skin quality, rule out concerns better suited to another approach, and explain the plan in English.
After about 20 to 30 minutes of topical numbing, the injections themselves usually take only 10 to 15 minutes.
A typical plan is 2 to 3 sessions spaced roughly 2 to 4 weeks apart, so the full course runs over several weeks.
Skin quality improves gradually over 3 to 6 weeks per session, with the fullest effect after the series is complete.
Results are measured in months, so periodic maintenance is advised; gentle skincare and daily sunscreen help protect the delicate area.
Rejuran i is the under-eye specific polynucleotide (PN) formulation, tuned for the thin, delicate skin around the eyes, while standard Rejuran treats the face more broadly. Both use salmon-derived polynucleotides to stimulate collagen, but Rejuran i is injected more superficially. Learn more on our Rejuran Healer page.
No, Rejuran i is a biostimulator, not a volumising filler. It improves skin quality, crepiness, fine lines, and dullness by stimulating your own collagen and elastin, rather than filling a hollow. If your main concern is a true tear-trough shadow, the clinic’s doctors may suggest an injectable filler instead or alongside.
You may be suited if your under-eye concern is skin-quality driven, meaning crepey texture, fine lines, or dullness rather than a deep hollow. A consultation grades your skin thickness and pigmentation to confirm fit. Those with salmon allergy, pregnancy, or active eye-area infection are not suitable, which is reviewed beforehand.
Discomfort is usually mild because a topical anaesthetic is applied for about 20 to 30 minutes before injection. The under-eye area is sensitive, so you may feel small pinpricks, but most patients tolerate it well. Fine needles and superficial placement help keep the delicate periorbital zone comfortable throughout the short session.
Downtime is minimal for most people, typically just tiny pinpoint marks or occasional light bruising that settles within a few days. Because the under-eye skin is thin, small bruises are possible, so many patients schedule around events. Gentle skincare and cold compresses help, and makeup can usually be applied the next day.
Improvement is gradual, usually building over 3 to 6 weeks after each session as new collagen and elastin form. Unlike a filler, there is no instant change; the skin looks progressively firmer, smoother, and less dull. The fullest effect appears after your short series of sessions is complete.
Most plans use about 2 to 3 sessions spaced roughly 2 to 4 weeks apart, since polynucleotide works cumulatively. The exact number depends on your under-eye condition and how your skin responds. Your doctor reviews progress between visits and adjusts the plan across the course as needed.
Results are typically measured in months rather than being permanent, because the stimulated collagen naturally turns over. Rejuran i is not a one-time fix, so periodic maintenance sessions help sustain the improvement. Your doctor will suggest a maintenance interval based on your skin and the results you achieve.
Rejuran i can help under-eye dullness that stems from thin, poorly circulated skin, because polynucleotide improves microcirculation and skin density. However, dark circles caused by deep hollows or pigmentation may need a different approach. A consultation identifies the cause first; pigment concerns may pair with laser treatment.
Yes, Rejuran i is often staged with other treatments, such as filler for a true hollow or standard Rejuran for the wider face. Combining is planned carefully so the delicate eye area is not over-treated. Your doctor sequences procedures across visits; the broader Rejuran range may also be discussed.
Rejuran i is widely used and generally well tolerated when injected by a trained doctor, with mostly minor effects like transient bruising or pinpoint marks. Because it is salmon-derived, those with fish allergy should avoid it. A consultation screens contraindications such as pregnancy or active infection to keep the delicate eye area safe.
The most common side effects are temporary and local, including small bruises, redness, mild swelling, or pinpoint marks that settle within days. Serious reactions are uncommon. Because the under-eye skin is thin, bruising is the most frequent issue. Your doctor explains what to expect and how to minimise it before treatment.
Rejuran i is itself a type of skin booster, specifically a polynucleotide biostimulator for the eye area, whereas hydrating skin boosters mainly add moisture. Rejuran i additionally stimulates collagen and elastin. Your doctor may compare it with other injection treatments to match your goals and skin type.
Aftercare is simple: keep the area clean, avoid rubbing or heavy makeup for a day, and use gentle skincare with daily sunscreen. Avoid saunas, intense exercise, and alcohol for a day or two to reduce bruising. Your doctor gives tailored guidance, especially useful if you are travelling after treatment.
Our Incheon Airport (Yeongjongdo) location, near ICN, offers Rejuran i with English-language support, which is convenient for travellers and stopovers. Reberry Clinic has three Seoul-area locations, so you can also be seen in Gangnam or Myeongdong. Message us to confirm the most convenient option for your itinerary.
For a single session, even 1 day works, since the appointment is short and downtime is minimal. However, because Rejuran i is a series, many international patients plan the first session near ICN and continue on later visits. Our English-speaking team helps coordinate timing around your travel schedule.
Yes, most patients can fly within a day, as Rejuran i is minimally invasive. Cabin air is drying, so moisturise gently and avoid rubbing the treated area. If you bruise easily, allow a little buffer before big events. Being near ICN makes it convenient to treat and travel on the same trip.
International patients can begin a Rejuran i series in Korea and continue it across return visits, with English-language remote check-ins between trips to keep the plan on track. Your treatment notes are kept on file for continuity, and supportive skin care at home helps maintain results.
| Rejuran i (under-eye PN) | Under-Eye HA Filler | Standard Rejuran (Healer) | |
|---|---|---|---|
| Energy / mechanism | Polynucleotide biostimulator, salmon-derived | Hyaluronic acid gel that adds volume | Polynucleotide biostimulator for the whole face |
| Best for | Crepey, thin, dull under-eye skin quality | A true hollow or tear-trough shadow | Overall facial skin quality and fine lines |
| Pain / comfort | Mild, topical numbing used | Mild to moderate, numbing used | Mild, topical numbing used |
| Downtime | Minimal, possible pinpoint marks or light bruising | Possible bruising and short-lived swelling | Minimal, possible small bumps that settle |
| Results timeline | Gradual over 3 to 6 weeks, builds across sessions | Immediate volume, settles over 1 to 2 weeks | Gradual over several weeks across a series |
| Longevity | Months, then maintenance top-ups | Often longer per session but volume can migrate | Months, maintenance recommended |
| Cost context | Depends on sessions in the series | Depends on product volume used | Depends on sessions and area treated |
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