Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices · Featured in Authority Magazine (2026)
Rejuran uses salmon-derived polynucleotides to stimulate your own fibroblasts, typically over a series of about 3 sessions spaced 2 to 4 weeks apart, improving skin quality rather than adding volume.
Rejuran is a polynucleotide (PN) skin booster that improves skin texture, elasticity, hydration, and fine lines by stimulating your own collagen and elastin. Salmon-derived polynucleotides act as a biostimulator, not a volumising filler, over about 3 sessions. At our Incheon Airport (Yeongjongdo) location near ICN, it suits travellers wanting a K-beauty skin-quality boost.
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Rejuran is a polynucleotide (PN) skin booster, one of Korea’s best-known regenerative injectables. Rather than adding volume like a hyaluronic acid filler, it improves the underlying quality of the skin: texture, firmness, elasticity, hydration, and fine lines. It is injected as a series of micro-deposits across the treatment area, where it works from within to rebuild the dermis over the following weeks. Many international patients seek it out as part of a K-beauty skincare journey.
The active ingredient is polynucleotide, a long chain of nucleotides purified from salmon DNA. Once in the skin it acts as a biostimulator, signalling fibroblasts to produce new collagen and elastin, improving microcirculation, and helping the skin hold moisture. This is why results are gradual and quality-based rather than instant: over several weeks the skin typically looks smoother, more elastic, and healthier, with a natural glow rather than an inflated or filled appearance.
At Reberry Clinic, Rejuran is consultation-led. The clinic’s doctors confirm whether a PN skin booster fits your goals, or whether a filler, laser, or another approach would serve better, and design a short series accordingly. International patients are supported in English at our Incheon Airport (Yeongjongdo) location near ICN, which is convenient for a stopover or the beginning of a Seoul itinerary.
Rejuran works through polynucleotide (PN), a purified salmon-derived DNA fragment, not through hyaluronic acid volume or heat energy. When injected into the dermis, the polynucleotide behaves as a biostimulatory scaffold: it stimulates fibroblasts to synthesise new collagen and elastin, enhances local microcirculation, and improves the skin’s water-binding capacity. Because the mechanism is regenerative rather than space-filling, the change appears gradually over roughly 3 to 6 weeks as the dermis remodels. Across a series of about 3 sessions spaced 2 to 4 weeks apart, the skin becomes denser and more elastic, so texture refines, fine lines soften, and the surface looks more even and hydrated. This is fundamentally different from a filler, which physically occupies space to create contour or volume, and different again from energy devices like RF or ultrasound, which use heat to trigger tightening. The clinic’s doctors match the mechanism to your concern; PN is often combined with those other modalities in a staged plan for a fuller result.
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The clinic’s doctors evaluate your skin quality and goals to confirm PN suits you, or whether 1 or more other modalities fit better.
A topical anaesthetic is applied for about 20 to 30 minutes so the injections are comfortable across the treatment area.
Polynucleotide is deposited as many tiny injections spaced a few millimetres apart, covering the area evenly within the dermis.
Over the next 3 to 6 weeks the PN signals fibroblasts to build collagen and elastin, improving density, elasticity, and hydration.
Most plans use about 3 sessions spaced 2 to 4 weeks apart, with results accumulating across the course rather than after one visit.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors assess your skin quality and goals, confirm PN fits, and explain the plan and expected timeline in English.
After about 20 to 30 minutes of topical numbing, the injections themselves usually take about 15 to 20 minutes.
A typical course is about 3 sessions spaced 2 to 4 weeks apart, so the full plan runs over several weeks.
Skin quality improves gradually over 3 to 6 weeks per session, with the fullest effect after the series is complete.
Results last months, so periodic maintenance is advised; gentle skincare and daily sunscreen help protect and prolong them.
Rejuran is a polynucleotide (PN) skin booster made from salmon-derived DNA fragments that improve skin texture, elasticity, hydration, and fine lines. It works as a biostimulator, prompting your own collagen and elastin, rather than adding volume like a filler. You can read more on our Rejuran Healer page.
No, Rejuran is not a volumising filler. It is a biostimulator that improves the skin’s own quality, texture, elasticity, hydration, and fine lines, rather than filling hollows or creating contour. If you want volume, the clinic’s doctors may suggest an injectable filler instead or alongside Rejuran.
Most adults wanting better skin quality, dull, rough, or early-aging skin, are suitable candidates. A consultation confirms whether PN fits your goals or whether another modality would serve better. Those with salmon allergy, pregnancy, or active skin infection are not suitable, which is reviewed before any treatment.
Discomfort is usually mild because a topical anaesthetic is applied for about 20 to 30 minutes before injection. You may feel small pinpricks as the many micro-injections are placed, but most patients tolerate it well. Fine needles and numbing keep the multiple-injection technique comfortable across the treatment area.
Downtime is minimal for most people, usually just small injection marks, mild redness, or occasional light bruising that settles within a few days. Because Rejuran is placed as many tiny deposits, you may see temporary small bumps that flatten quickly. Makeup can typically be applied the next day.
Results are gradual, usually building over 3 to 6 weeks after each session as new collagen and elastin form. There is no instant change like a filler; instead the skin looks progressively smoother, more elastic, and healthier. The fullest effect appears after your series of about 3 sessions is complete.
Most plans use about 3 sessions spaced 2 to 4 weeks apart, since polynucleotide works cumulatively. The exact number depends on your skin condition, age, and goals. Your doctor reviews progress between visits and adjusts the plan, then recommends a maintenance interval afterwards for lasting results.
Results typically last several months rather than being permanent, because the stimulated collagen naturally turns over. Rejuran is not a one-time fix, so periodic maintenance sessions help sustain the improvement. Your doctor suggests a maintenance schedule based on your skin and the results you achieve over the series.
Rejuran uses polynucleotide to improve texture and elasticity, while Juvelook uses PDLLA to stimulate collagen with a longer-building, firmness-focused effect. Both are biostimulators rather than volumising fillers, and they suit slightly different goals. Learn more about Juvelook to compare which fits you.
Yes, Rejuran is frequently combined with lasers, energy-based lifting, or fillers in a staged plan for a fuller result. Combining is sequenced carefully so the skin is not over-treated. Your doctor may pair it with laser treatment for tone and texture, planned across separate visits.
Rejuran is widely used and generally well tolerated when injected by a trained doctor, with mostly minor effects such as transient bruising or small bumps. Because it is salmon-derived, those with fish allergy should avoid it. A consultation screens contraindications like pregnancy or active infection to keep treatment safe for your skin.
The most common side effects are temporary and local: small bruises, redness, mild swelling, or injection marks that settle within days. Serious reactions are uncommon. Because Rejuran is placed as many small injections, transient bumps are typical and flatten quickly. Your doctor explains what to expect before you start.
Rejuran can improve overall skin texture and some shallow irregularities by boosting collagen, which may soften the look of pores and mild texture. Deeper acne scars usually need combination treatment. A consultation grades your skin; your doctor may pair Rejuran with an acne treatment plan for scarring.
Aftercare is simple: keep the area clean, avoid heavy makeup and rubbing for a day, and use gentle skincare with daily sunscreen. Avoid saunas, intense exercise, and alcohol for a day or two to reduce bruising. Your doctor gives tailored guidance, which is especially helpful if you plan to travel afterwards.
Our Incheon Airport (Yeongjongdo) location near ICN offers Rejuran with English-language support, which is convenient for travellers and stopovers. Reberry Clinic has three Seoul-area locations, so you can also be seen in Gangnam or Myeongdong. Message us to confirm the most convenient option for your itinerary.
For a single session, even 1 day works, since the appointment is short and downtime is minimal. However, because Rejuran is a series, many international patients start near ICN and continue on later trips. Our English-speaking team helps coordinate timing so your sessions fit around your travel plans.
Yes, most patients can fly within a day, as Rejuran is minimally invasive. Cabin air is drying, so moisturise and protect your skin from sun. If you bruise easily, allow a small buffer before big events. Being near ICN makes it easy to have treatment and travel on the same trip.
International patients can begin a Rejuran series in Korea and continue it across return visits, with English-language remote check-ins between trips to keep the plan on track. Your treatment notes are kept on file for continuity, and a good skin care routine at home helps maintain results.
| Rejuran (PN) | Juvelook (PDLLA) | HA Skin Booster | |
|---|---|---|---|
| Energy / mechanism | Polynucleotide biostimulator, salmon-derived | PDLLA collagen stimulator | Hyaluronic acid micro-injections for hydration |
| Best for | Skin texture, elasticity, fine lines, glow | Firmness and collagen with a longer horizon | Surface hydration and a dewy look |
| Pain / comfort | Mild, topical numbing used | Mild, topical numbing used | Mild, topical numbing used |
| Downtime | Minimal, possible small marks or bruising | Minimal, possible small bumps that settle | Minimal, possible pinpoint marks |
| Results timeline | Gradual over 3 to 6 weeks across a series | Gradual, building over weeks to months | Fairly quick hydration, less collagen change |
| Longevity | Months, maintenance recommended | Often longer, months and beyond | Shorter, needs more frequent top-ups |
| Cost context | Depends on sessions and area | Depends on sessions and area | Depends on sessions and product used |
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