Gangnam
Dr. Yoongon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices
Rejuran is a polynucleotide (PN) skin booster that works across about 3 sessions to repair texture, elasticity, and resilience from within.
Rejuran is a polynucleotide (PN) skin booster made from purified salmon DNA fragments, micro-injected into the dermis to repair skin quality from within. It improves elasticity, hydration, and fine texture gradually over a course of roughly three sessions, rather than adding volume like a filler does.
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Rejuran is a skin-healing booster built on polynucleotides (PN), long chains of purified DNA fragments derived from salmon. Unlike a hyaluronic acid filler that physically lifts tissue, Rejuran is injected into the dermis to support the skin’s own repair processes, gradually improving elasticity, hydration, and fine texture. It is best understood as a skin-quality treatment, not a volumiser.
The polynucleotides act as a biological scaffold that encourages fibroblasts to produce new collagen and helps the skin retain water. Because the effect is regenerative rather than mechanical, results appear progressively over a course of treatments rather than instantly. Most plans involve about three sessions spaced two to four weeks apart, followed by periodic maintenance.
For international patients, Rejuran is a popular reason to visit Seoul, where it originated. Reberry Clinic serves visitors across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport), with English-language consultation and treatment planned and reviewed by the clinic’s doctors.
Rejuran uses polynucleotides: high-molecular-weight DNA fragments purified from salmon milt and processed to remove proteins, so the material is biocompatible. When micro-injected into the dermis, these polynucleotide chains form a temporary matrix that signals fibroblasts to increase collagen and elastin production and improves the skin’s ability to hold moisture. The mechanism is regenerative, working with the skin’s natural repair pathway rather than freezing muscle or filling space. This is why Rejuran is grouped with biostimulating skin boosters rather than with neuromodulators or hyaluronic acid fillers, and why its benefits build over weeks instead of appearing immediately.
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The clinic’s doctors review your skin quality and plan an injection map, typically across 1 full-face session per visit.
Topical anaesthetic is applied for about 20 to 30 minutes so the micro-injections are comfortable.
Polynucleotide gel is placed into the dermis through many small injection points, usually completed in 15 to 20 minutes.
Over the following 2 to 4 weeks, fibroblasts increase collagen and the skin retains more moisture.
A typical plan is about 3 sessions spaced 2 to 4 weeks apart, with results compounding through the course.
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors assess your skin quality, discuss goals, and recommend how many sessions suit you, explained in English.
After numbing, the micro-injection session itself takes about 15 to 20 minutes, with the visit lasting under an hour.
A full plan is usually about 3 sessions spaced 2 to 4 weeks apart, with optional maintenance later.
Texture and elasticity improve gradually over weeks, with the fullest effect after the course is complete.
Effects last several months; gentle skincare, sun protection, and periodic top-ups help maintain them.
Rejuran is a polynucleotide (PN) skin booster made from purified salmon DNA fragments that repair skin quality from within. It improves elasticity, hydration, and fine texture rather than adding volume. You can see the full protocol on our Rejuran Healer page, which explains how the course is planned.
No, Rejuran is a regenerative skin booster, not a volumising filler. It works by signalling your skin to repair itself, improving texture and elasticity over a course of sessions. If your goal is to add structural volume instead, our injectable fillers page explains how hyaluronic acid fillers differ.
Adults with thin, fragile, dull, or ageing skin who want to improve quality rather than add volume are ideal candidates. It suits people seeking a regenerative, natural-looking approach. A consultation confirms suitability and rules out salmon allergy. Skin that is currently inflamed or infected should be treated first.
Most patients describe mild stinging during the micro-injections, which is well managed with topical numbing applied for 20 to 30 minutes beforehand. The injections take only 15 to 20 minutes. Any discomfort is brief, and a fine needle or injector is used to keep the experience comfortable throughout.
Downtime is minimal: expect tiny raised bumps at injection points plus mild redness for one to two days as the gel settles. Some bruising can occur but is usually minor. Most international visitors continue light sightseeing the next day and can cover any redness with gentle makeup.
Rejuran works gradually, so the main improvements in elasticity and texture build over several weeks as collagen forms. Many patients notice smoother, more hydrated skin after the second session. Studies measured significant elasticity gains by 12 weeks. Results are progressive across the course rather than immediate after one visit.
A typical Rejuran plan is about three sessions spaced two to four weeks apart, allowing the regenerative effect to compound. Some patients with very thin or stressed skin benefit from additional sessions. Your doctor recommends the right number at consultation based on your skin condition and goals.
Results commonly last several months, after which periodic maintenance sessions help sustain the improvement. Because Rejuran supports your own skin repair, natural ageing continues over time. Many patients schedule a top-up every few months. Pairing it with good skin care helps extend the benefit you achieve.
Yes, Rejuran is frequently combined with lasers, energy lifting, or other boosters, sequenced safely by your doctor for complementary effects. Many patients pair it with a hydration booster for added glow. You can read about a related collagen-stimulating option on our Juvelook page to understand how they differ.
Rejuran has a well-documented safety profile, with the purified polynucleotide material processed to remove proteins for biocompatibility. Side effects are usually limited to temporary redness, swelling, or small bumps. Serious reactions are rare. Your doctor reviews your history, including any salmon allergy, to keep the treatment safe for you.
Expect temporary redness, minor swelling, small bumps at injection points, and occasional light bruising for a day or two. These resolve on their own. Less common reactions include tenderness or transient itching. Serious complications are rare when an experienced doctor performs the injections using appropriate technique and sterile conditions.
Rejuran uses polynucleotides to repair and strengthen skin structure, while many glass-skin boosters use hyaluronic acid mainly for hydration and glow. They target different goals and are often used together. Our glass-skin booster page explains the hydration-focused approach in more detail.
Aftercare is simple: keep the area clean, avoid makeup for the rest of the day, and skip saunas, intense exercise, and alcohol for a couple of days. Protect skin from sun and stay hydrated. Your clinic provides written aftercare so you can follow it confidently once you travel home.
For a single session you need only one to two days, covering consultation and treatment with minimal downtime. If you want to complete part of a course, your team can schedule sessions across a longer stay or plan follow-ups for a return trip. Our English team coordinates timing around your travel.
Yes, flying soon after Rejuran is generally fine, often the next day, because it is a minimally invasive injectable with only minor swelling. Stay hydrated during the flight and avoid touching or pressing the treated skin. If you had extensive treatment, your doctor will advise any specific timing before you travel.
International patients can have remote check-ins in English after returning home, with progress reviewed as results develop over the weeks. If you want to continue your course or add care later, you can explore related options such as glass-skin boosters. Your treatment notes are kept on file for any future visit.
There is no single right age; Rejuran suits adults from their twenties wanting prevention through to older patients seeking repair of thinning, less elastic skin. Younger patients often use it for texture and glow, while mature skin benefits from the regenerative effect. A consultation tailors the plan to your skin’s current condition.
| Rejuran | Juvelook | Skin booster (HA) | |
|---|---|---|---|
| Active / mechanism | Polynucleotide (PN, salmon DNA), regenerative repair | PDLLA collagen stimulator | Hyaluronic acid micro-droplets, hydration |
| Best for | Elasticity, texture, fragile skin | Gradual collagen building and firmness | Deep, lasting hydration and glow |
| Pain / comfort | Mild stinging, managed with numbing | Mild stinging, managed with numbing | Mild, managed with numbing |
| Downtime | Tiny bumps and redness for a day or two | Mild redness and small bumps briefly | Minimal, brief redness |
| Results timeline | Builds over weeks across about 3 sessions | Builds over 2 to 3 months | Hydration within days, refines over weeks |
| Longevity | Several months, maintained with top-ups | Often up to a year or more | Several months, varies |
| Sessions | Usually a course of about 3 | Usually 2 to 3 spaced sessions | Often a short series |
| Cost context | Consultation-led; depends on sessions and area | Consultation-led; depends on vials used | Consultation-led; depends on product and area |
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