Gangnam
Dr. Yoon-Gon Ryu
Aesthetic Medicine Specialist
Flagship clinic · KOL for leading lifting & regenerative devices · Featured in Authority Magazine (2026)
Rejuran HB combines salmon polynucleotide with hyaluronic acid in 1 injectable to hydrate and repair skin across a series of sessions.
Rejuran HB is a hydra-booster that combines salmon-derived polynucleotide with hyaluronic acid in one injectable. The polynucleotide stimulates fibroblasts and skin repair while the hyaluronic acid adds immediate hydration and plumping. Delivered over a short series of sessions, it improves skin texture, elasticity, and glow with minimal downtime.
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Rejuran HB is a regenerative skin booster that pairs two ingredients in a single injectable: salmon-derived polynucleotide (PN) and hyaluronic acid (HA). The ‘HB’ stands for hydra-booster, reflecting its dual role of repairing skin from within while delivering instant hydration, which sets it apart from the original Rejuran formula focused mainly on repair.
The polynucleotide component works at a cellular level to stimulate fibroblasts, support collagen and elastin production, and calm inflammation, gradually improving skin quality over weeks. The hyaluronic acid component binds water in the dermis, so skin looks plumper, smoother, and more luminous soon after treatment. Together they target dehydration, dullness, fine lines, and loss of firmness.
At Reberry Clinic, Rejuran HB is administered by the clinic’s doctors as a planned course, with English-speaking support for international patients across three Seoul-area locations (Gangnam, Myeongdong, Incheon Airport). The plan is tailored to your skin condition rather than a fixed protocol.
The active polynucleotide in Rejuran HB is a chain of nucleotides extracted and purified from salmon DNA, chosen because it is highly biocompatible with human tissue. Once injected into the dermis, it activates fibroblasts and adenosine receptors, increasing collagen and elastin synthesis, promoting micro-circulation, and reducing inflammatory signalling, which together improve the skin’s structure and resilience. The hyaluronic acid in the formula acts immediately, drawing and holding water to hydrate and plump the treated layer. Because polynucleotide drives gradual regeneration while hyaluronic acid gives instant hydration, results appear in two phases: an early glow from hydration, followed by progressive texture and elasticity gains as new collagen matures over the weeks after each session.
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The doctor assesses skin hydration, texture, and elasticity to plan a course, often 2 to 4 sessions spaced about 2 to 4 weeks apart.
Topical anaesthetic is applied for about 20 to 30 minutes so the micro-injections are comfortable.
The HB formula is placed as dozens of tiny intradermal deposits, spaced a few millimetres apart, for even coverage.
Hyaluronic acid binds water immediately, so skin looks plumper and more luminous within the first 1 to 3 days.
Polynucleotide stimulates fibroblasts, with texture and elasticity improving progressively over 4 to 8 weeks.
Reberry Clinic · Prices verified: Oct 2026
| Clinic | Price (KRW) |
|---|---|
| All Reberry Clinic locationsRejuran HB 1cc | from₩230,000 |
VAT excluded · Final price depends on treatment scope and skin condition · Confirmed after consultation
See representative outcomes from Reberry Clinic. Results build gradually and vary by individual; your plan is assessed at consultation.
The clinic’s doctors assess your skin and plan a course, usually 2 to 4 sessions, explained in English.
After numbing, the micro-injection session takes about 20 to 40 minutes depending on the area.
Most patients return to normal activities the same day, with only tiny injection bumps that settle in hours.
An early hydration glow appears within days, with texture and elasticity building over 4 to 8 weeks.
Effects last several months when maintained with a series; use sun protection and gentle skincare.
Rejuran HB is a hydra-booster that combines salmon-derived polynucleotide with hyaluronic acid in one injectable, so it both repairs skin and hydrates it. The polynucleotide stimulates fibroblasts while the hyaluronic acid plumps immediately. You can read about the polynucleotide repair family on our Rejuran Healer page.
Regular Rejuran focuses on polynucleotide repair, while Rejuran HB adds hyaluronic acid for immediate hydration and plumping, giving a faster visible glow alongside the regeneration. HB suits dehydrated, dull skin especially well. To compare the repair-focused version, see our Rejuran Healer page for the original formula.
Adults with dehydrated, dull, or early-ageing skin who want better texture, elasticity, and glow are ideal candidates. It also suits those wanting a regenerative option with minimal downtime. A consultation confirms suitability. For volume-focused concerns instead, you might consider our Juvelook page.
Discomfort is mild and brief because numbing cream is applied first, and the injections are tiny intradermal microdroplets. Most patients describe small stings rather than pain. Sensitive areas may feel a little more, but the session is short and any tenderness fades quickly after you leave the clinic.
Downtime is minimal: most patients have tiny injection bumps and slight redness that settle within a few hours to a day. Light bruising is possible but uncommon. Because there are no dressings or restrictions beyond gentle aftercare, international visitors can usually continue sightseeing soon after the appointment.
You often notice an early hydration glow within the first few days from the hyaluronic acid, while the deeper texture and elasticity improvements from polynucleotide build progressively over about 4 to 8 weeks. Results accumulate across the planned series, so the full benefit appears after completing your sessions.
Results commonly last several months when the recommended series is completed, after which maintenance sessions sustain the improvement. Because Rejuran HB stimulates your own collagen, natural ageing continues over time. Pairing it with good skincare and sun protection, as covered on our skin care page, helps prolong the effect.
Most patients have a course of 2 to 4 sessions spaced about 2 to 4 weeks apart, then occasional maintenance. The exact number depends on your skin condition and goals, which the doctor confirms at consultation. International patients can often complete two sessions within a single longer stay if timed well.
Yes, Rejuran HB is frequently combined with treatments like botox or energy-based lifting for complementary results, sequenced safely by your doctor. It pairs especially well with procedures that target firmness rather than hydration. You can explore the wider range of injectables on our injection treatment page.
Rejuran HB has a strong safety profile when administered by trained doctors, and salmon-derived polynucleotide is highly biocompatible with human skin. Side effects are usually limited to temporary redness, swelling, or small bumps. Your doctor reviews your history first, since allergies to salmon ingredients or pregnancy mean it is not suitable for everyone.
Expect mild, temporary redness, slight swelling, and tiny injection bumps that resolve within hours to a day. Light bruising can occur but is uncommon and self-resolving. Serious reactions are rare when an experienced doctor performs the treatment. Following the aftercare advice helps your skin settle smoothly and comfortably.
Aftercare is gentle and simple: keep the skin clean, avoid makeup for the rest of the day, and skip saunas, intense heat, and heavy exercise for about 24 hours. Use sun protection and a mild moisturiser. Your clinic provides written guidance so you can follow it confidently once you travel home.
Fillers add structural volume to lift and contour, whereas Rejuran HB improves overall skin quality, hydration, and elasticity rather than adding bulk. Many patients use both for different goals. To understand volumising options, see our injectable fillers page, which serves a different purpose from this booster.
A single Rejuran HB session needs only a day, since it takes about 20 to 40 minutes with minimal downtime. If you want two sessions in one trip, plan a stay of around two to three weeks, or schedule the rest on a return visit. Our English-speaking team coordinates the timing for you.
International patients can have remote check-ins in English to review progress and plan remaining or maintenance sessions around their travel. Your treatment notes are kept on file for any return visit. You can also continue supportive care between sessions using our skin care options at home.
| Rejuran HB | Rejuran Healer | Juvelook | |
|---|---|---|---|
| Mechanism | Salmon polynucleotide plus hyaluronic acid | Salmon polynucleotide for repair | PDLLA collagen stimulator |
| Best for | Dehydration plus texture and firmness | Skin repair, redness, fine lines | Volume loss and collagen rebuilding |
| Pain / comfort | Multiple micro-injections, numbing used | Multiple micro-injections, numbing used | Micro-injections, numbing used |
| Downtime | Minimal, small bumps settle in hours | Minimal, possible brief redness | Minimal, possible swelling |
| Results timeline | Early glow, builds over weeks | Builds over weeks | Gradual over weeks to months |
| Longevity | Several months, maintained with a series | Several months with a series | Often a year or more |
| Sessions | Usually 2 to 4 spaced sessions | Usually 3 to 4 sessions | Usually 1 to 3 sessions |
Real verified reviews from our Google Business Profile, across all Reberry Clinic locations.
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Your treatment is planned and performed by experienced, MFDS-registered doctors across our Seoul-area clinics, with multilingual support for international patients.
Flagship clinic · KOL for leading lifting & regenerative devices · Featured in Authority Magazine (2026)
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